6047348
Descrição
FlashCards por Emma Allde, atualizado more than 1 year ago
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Criado por Emma Allde
quase 8 anos atrás
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| Questão | Responda |
| Sickle cell disease is due to which mutation resulting in abnormally folded haemoglobin (HbS) | Glu -> Val |
| The misfolded HbS results in what characteristic | Polymerisation |
| Polymerised haemoglobin have what characteristics | Crystallised chain structures which disrupt the membrane of red blood cells |
| Alzheimer's disease is mostly likely the result of what | formation of stable aggregations of proteins and amyloid proteins forming plaques |
| Creutzfeldt-Jakob's disease is the result of what | stable aggregations of proteins called prions |
| What is a prion | A protein that can fold in multiple, structurally distinct ways, at least one of which is transmissible to other prion proteins |
| Where are proteins found | on the surface of cells |
| Prion protein polymerisation results in conversion of normal PrPC into what | pathogenic form PrSC |
| Polymerisation of the pathogenic form (PrPSC) in CJD forms what | fibrils (aggregates) |
| Structure of normal prion proteins (PrPC) | Alpha helical, susceptible to proteolysis |
| Structure of pathogenic prion proteins (PrPSC) | Beta sheet becomes present, protease resistant so it accumulates Identical amino-acid sequence to normal prion protein |
| Neurological symptoms of CJD (5) | Difficulties with walking, slurred speech, numbness, dizziness, visual problems |
| Psychological symptoms of CJD (5) | Severe depression, withdrawal, anxiety, irritability, insomnia |
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