at 1st 72 hrs of life :-baby with TSB more than 25 mg/dl / 38wks of gestation
Rx------------------------------------------------------------------------------------------------------------------
1-blood + cross match .
2-Exchange transfusion
3-intensive photo therapy.
4- (2-3hr need to monitoring TSB =>Still more 20-25 mg/dl=>repeat in (3-4hrs)=>reduce to 20mg/dl =>repeat in (4-6hrs) =>fall =>repeat in (8-12hrs) =>TSB <13-14mg/dl ==>DISCONTINUE PHOTO-THERAPY.
5-after (24 hrs) measurement TSB
6- WHEN EVER DETECT KERNICTERUS SIGNS ==> EMERGENCY ROOM
If case with infant who suffer from isoimmune hemolytic disease + TSB rising
Rx--------------------------------------------------------------------------------------------------------
0- exchange transfusion if sever risk ! anemia /hyper-bilirubin
TSB >5 mg/dl , Hb <10 mg
1-intensive photo-therapy
2-IVIG 0.5-1g/kg over 2hrs & repeat 12 hr IF NECESSARY.
3- use TOTAL BILIRUBIN don't subtract direct (conjugated )bilirubin.
IF unusual situation Direct bilirubin level equal or more 50% than total bilirubin NEED consultation with an expert pediatric gastro-enterologist.
4- some physicain refer to ER if Retic count >15 %
previous K or erythroblastosis rapidly
increase TSB & prematurity
IN CASE OF PREMATURE INFANT less than 35 wks of gestation THE therapy will depending on :-
1-GA .
2-INFANT CONDITION.
3-RISK FACTOR TO DEVELPED KERNICTEURES AT LOWER LEVEL.
Rx------------------------------------------------------------------------------------------------------------------------
1-photo-therapy
2-Exchange -transfusion