101729
Descrição
Mapa Mental por jessica.neilan, atualizado more than 1 year ago
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Criado por jessica.neilan
mais de 11 anos atrás
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ADH - Anti-Diuretic Hormone
- Hydrated people have large amounts of diluted urea in their urine
- Dehydrated people have small amounts of concentrated urea in their urine
- ADH is a 9 amino peptide
- Synthesised in neuroendocrine cells in the supraoptic and parvoventricular nuclei of the hypothalamus
- It is transported along the axons of these cells and stored in the neurohypophysis (posterior pituitary)
- It is transported along the axons of these cells and stored in the neurohypophysis (posterior pituitary)
- Conserves water by producing concentrated urine
- Increases the medullary collecting duct permeability to water
- Inserts AQP2 channels into the apical membrane of principal cells
- ADH
- V2 receptor
- Gs protein
- Adenylyl cyclase
- Increased cAMP level
- Protein Kinase A
- Synthesis and insertion of AQP2 channels into apical membrane
- Synthesis and insertion of AQP2 channels into apical membrane
- Protein Kinase A
- Increased cAMP level
- Adenylyl cyclase
- Gs protein
- V2 receptor
- ADH
- Inserts AQP2 channels into the apical membrane of principal cells
- Increases the permeability of the inner medullary collecting duct to urea
- Activates a cAMP protein cascade that phosphorylates the urea transporters on the apical membrane UT-A1 and UT-A3
- Increased urea in interstitium increases osmalarity of interstitium and causes reabsorbtion of water by osmosis
- Increased urea in interstitium increases osmalarity of interstitium and causes reabsorbtion of water by osmosis
- Activates a cAMP protein cascade that phosphorylates the urea transporters on the apical membrane UT-A1 and UT-A3
- Also increases Na absorption by increasing the number of NaK2Cl symporters in thick ascending limb
- Trigerrs for ADH: osmoreceptors detect a 2% hyperosmalarity and baroreceptors detecta 15% pressure fall
- ADH can also act on V1 receptors to cause vasoconstriction and slow blood flow of vasa recta for longer time of equilibration
- MInimises washout of solutes in inner medulla that causes reabsorption of water
- MInimises washout of solutes in inner medulla that causes reabsorption of water
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