Celiac Disease

It affects
1. small intestine
  1. Anatomy of the small intestine
  2. Histology
Pathophysiology
Associated Conditions
1. Type 1 diabetes mellitus
2. Autoimmune hepatitis
3. Sjögren’s syndrome
4. Multiple Sclerosis
5. Addison disease
6. Arthritis
Complications
1. Osteoporosis
2. Lactose intolerance
3. Lymphoma and small bowel cancer
4. Infertility
5. Iron deficiency anemia
  1. Causes
    1. Blood loss
    2. lack of iron in your diet
    3. inability to absorb iron
    4. Pregnancy
6. steatorrhea
  1. Causes
    1. cystic fibrosis
    2. chronic pancreatitis
    3. lactose intolerance
    4. Whipple disease
The differences with IBS
Sign & symptoms
1. Diarrhea
2. Bloating
  1. Fatigue
    1. Abdominal discomfort
      1. weight loss
        Joint pain
        GERD and heartburn
Part of
1. Malabsorption syndromes
  1. Intraluminal
    1. Pancreatic insufficiency
    2. Bile acid/salt deficiency
  2. Brush border
    1. Infective enterocolitis
  3. Lymphatic transport
    1. whipple’s disease
  4. It affects
    1. GI system
      1. Physical examination
        Introduction
        Inspection
        Clubbing, leukunychia
        Palmar erythema, Duputyren's contracture
        spider navi, gynecomastia
        Ascites, campus medusa
        Palpation & percussion
        Auscultatoin
        Rectal Examination
Screening
1. Anti – tissue Transglutaminase Antibody
2. (IgA) test
3. anti-DGP
4. Anti-endomysial antibodies
5. Anti-reticulin antibody
Investigations
1. Endoscopy
2. Biopsy
3. CBC  anemia
4. Stool fat
5. CT
Treatment
1. Lifelong Adherence to the Gluten-Free Diet
  1. Avoid
    1. Wheat
    2. Barley
    3. Rye
2. Vitamins and Dietary Supplements
  1. , iron, calcium, magnesium, zinc,
  2. folate, niacin, riboflavin, vitamin B12, and vitamin D
Role of registered dietition
1. Assess nutritional status
2. Counsel
3. Assess Psychosocial status
4. Adress comorbidities
Prognosis
1. untreated or unresponsive celiac disease have increased early mortality
Epidemiology

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Celiac Disease

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	Criado por Eslam Ebrahim mais de 6 anos atrás