Breast cancer

Descrição

Mapa Mental sobre Breast cancer, criado por Fatima Alkhateeb em 24-02-2019.
Fatima Alkhateeb
Mapa Mental por Fatima Alkhateeb, atualizado more than 1 year ago
Fatima Alkhateeb
Criado por Fatima Alkhateeb mais de 5 anos atrás
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Resumo de Recurso

Breast cancer
  1. Anatomy of the breast
    1. Blood supply
      1. Lymphatic drainage
      2. Risk factors
        1. Early menarche
          1. Not breastfeeding
            1. Using hormone replacement therapy
              1. Obesity
              2. Signs and symptoms
                1. Change in breast size or shape
                  1. Nipple discharge
                    1. Lump in the breast
                      1. Redness, dimpling of the skin
                      2. Tumors of the breast
                        1. Benign
                          1. Fibroadenoma
                            1. Small, well-defined, mobile mass, increased size and tenderness with high estrogen, women < 35 years old
                            2. Intraductal papilloma
                              1. Small fibroepithelial tumor within lactiferous ducts, typically beneath areola, most common cause of nipple discharge
                              2. Phyllodes tumor
                                1. Large mass of connective tissue and cysts with “leaf-like” lobulations, most common in 5th decade
                              3. Malignant
                                1. Non-invasive
                                  1. DCIS
                                    1. Fills ductal lumen (neoplastic cells in duct; engorged blood vessel). Arises from ductal atypia. Often seen early as microcalcifications on mammography
                                      1. Cribriform type
                                        1. Comedo type
                                          1. Central necrosis
                                      2. LCIS
                                        1. Proliferation of cells in lobules, Discohesive growth, round cells clumped together
                                        2. Paget's disease
                                          1. Results from underlying DCIS or invasive breast cancer. Eczematous patches on nipple . Paget cells = intraepithelial adenocarcinoma cells.
                                        3. Invasive
                                          1. Invasive ductal carcinoma
                                            1. Firm, fibrous, “rock-hard” mass with sharp margins and small, glandular, duct-like cells. Tumor can deform suspensory ligaments. Classic morphology: “stellate” infiltration
                                            2. Invasive lobular carcinoma
                                              1. Orderly row of cells (“single file”), due to loss of E-cadherin expression. Often bilateral with multiple lesions in the same location.
                                              2. Medullary carcinoma
                                                1. Fleshy, cellular, lymphocytic infiltrate, good prognosis
                                                2. Inflammatory breast cancer
                                                  1. Dermal lymphatic invasion by breast carcinoma. Peau d’orange (skin texture resembles orange peel due to edema leading to tightening of Cooper’s suspensory ligament)
                                            3. Physical examination
                                              1. Look for symmetry, irregular lumps, change in shape and size, tenderness, discharge
                                              2. Investigations
                                                1. FNA biopsy
                                                  1. very thin, hollow needle attached to a syringe used to aspirate tissue from suspicious area
                                                    1. Contraindications
                                                      1. coagulopathy or platelet disorder
                                                  2. Treatment and management
                                                    1. Surgery
                                                      1. chemotherapy
                                                        1. Radiation

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