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23085077
8.4 Transport of oxygen in the blood
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Biology Mapa Mental sobre 8.4 Transport of oxygen in the blood, criado por Joe Hitchings em 23-05-2020.
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biology
Mapa Mental por
Joe Hitchings
, atualizado more than 1 year ago
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Joe Hitchings
aproximadamente 4 anos atrás
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Resumo de Recurso
8.4 Transport of oxygen in the blood
Role of haemoglobin
Oxygen bind to haemoglobin to form oxyhaemoglobin
In respiring tissue O2 dissociates from oxyhaemoglobin
O2 then diffuses out of the erythrocytes to respiring cells
Haemoglobin can readily associate with O2 when there's are high conc of O2 and readily dissociate when there's a low conc.
Haemoglobin is comprised of 4 sub-units ( 2 alpha glucose, 2 beta glucose)
Each sub-unit is comprised of 1 polypeptide chain and 1 haem group with an iron ion at the centre
Each iron ion can reversably bind to O2
The haem group has an affinity for O2
Therefore O2 + haemoglobin = oxyhaemoglobin is a reversable reaction
Loading O2
Partial pressure = amount of pressure exerted by a gas relative to the total pressure exerted by all the gases in the mixture.
Measured in KPa and written as P(x)
How O2 is loaded
Haemoglobin doesn't absorb evenly
At low conc's the sub-units are tightly packed making it difficult for the first O2 to bind.
After the first O2 has bound there is a conformational change of the haemoglobin - making it easier for the 2nd and 3rd O2's to bind
Then its difficult for the 4th O2 to associate as the haemoglobin molecule is 'full'
Oxygen dissociation curve (Sigmoid curve)
Tissues(low Kpa)
P(O2) = 2-4 Kpa
A small decrease in P(O2) leads to a large decrease in % saturation
Haemoglobin has a low affinity for O2
Lungs (high KPa)
P(O2) = 10-12 KPa
A large decrease in P(O2) leads to a small decrease in % saturation
Haemoglobin has a high affinity for O2
Remember to read the graph from right to left
Foetal haemoglobin
Blood arrives at the placenta, low P(O2) (2-4 Kpa)
Haemoglobin has a low affinity for O2
At this point foetal haemoglobin has a higher affinity for O2
The adult haemoglobin dissociates with O2 releasing it to the placenta tissue when it will readily associate with foetal haemoglobin
Anexos de mídia
Hb O2 Dissociation Curve (binary/octet-stream)
Fh (binary/octet-stream)
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