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Pathophysiology: Immune-Mediated Atherosclerosis

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Brain storm showing the pathophysiology of immune-mediated AT.
Chadley Kemp
Mapa Mental por Chadley Kemp, atualizado more than 1 year ago
Chadley Kemp
Criado por Chadley Kemp mais de 9 anos atrás
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Resumo de Recurso

Pathophysiology: Immune-Mediated Atherosclerosis
  1. IL-1R
    1. IL-1R/IL-18
      1. NFkB TF
        1. Mp/DC (Innate)
          1. Alarmins
            1. LPS
              1. oxLDL
                1. LDL
                  1. CRP
                    1. oxLDL-CRP
                    2. Foam cells
            2. Caspase-1
              1. Inflammasome
            3. Local Inflammatory cascade
              1. IL-6
                1. Fibrinogen
                  1. Fibrin
                    1. Pro-coagulant
                      1. Thrombin
                2. FcRI/CD38
                  1. β2-GPI-spp Ab
                    1. Atheroma
                      1. Myocardial Infarction
                      2. oxLDL-β2GPI complex
                    2. MyD88
                      1. Th/Tc

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