BOD 1

1. Ovulatory dysfunction markers
2. Causes
   1. Lifestyle
   2. Infection
   3. Ovulatory disorders
      1. hyperprolactinemia
      2. Androgen excess
         1. CAH
      3. Hormone imbalance
         1. PCOS
      4. Hypothalamic pituitary insufficiency
3. Maintenance of pregnancy
   1. Common disorders
   2. Common complications

1. Effect on target tissues

1. Pathophysiology
2. Clinical markers

1. Insulin signalling
   1. Insulin receptor structure
   2. TK-IRS-p110-pip2>pip3-PKB
      1. PKB targets
         1. GSK3
         2. AS160
         3. TSC1/2
         4. FOXO
   3. Signalling defects
      1. IRS-1
      2. aPKC
2. Pathophysiology
   1. Effect of elevated glucose
      1. AGE/RAGE system
         1. Inflammation and mitochondria
   2. Effect of elevated lipids

1. Nephropathy
2. Retinopathy
3. Neuropathy
4. Athesclerosis

1. MODY
   1. 11 types and mutations
   2. Treatment
2. PNDM

1. Diet/exercise
2. Drug therapy
   1. Sulphonylureas
   2. Glitazones
      1. PPARY
   3. Metformin
      1. AMPK
   4. DPP4 inhibitors

1. Transcription factors
   1. SOX10
2. Ligands and receptors
   1. Endothelin-3 pathway
   2. Neurotrophin/RET pathway
3. Other candidate genes
   1. Phox-2b
   2. Ncx

1. Imaging methods
2. Conclusion from avian work

1. Mitochodria
   1. Myotubules
   2. Plectin Isoforms
2. Role in Sarcolemma and Costamere
   1. Functional role

1. Histological observations
   1. Calcification
   2. Fibrotic lesions
   3. Mitochondrial dissorganisation
      1. Number
      2. morphology
      3. Function
         1. ADP induced respiration
2. Mutations
   1. Phenotype
      1. Protein aggregates
         1. Pathogenesis
            1. processed by casp 6
            2. N termial product inhibits IF
            3. Apoptosis
         2. Treatment
            1. anti-apoptotic factors
            2. inc chaperone
            3. inc autophagy
               1. atg7
            4. inc proteosome
               1. pa28-alpha
      2. Apoptosis
         1. Anti-apoptotic factors Bcl-2

1. Ubiquitination
   1. Cardiac Calpain-1

1. Macro
2. Micro
3. CMA
   1. Sarcomere specialised chaperones
      1. Myosin
         1. Hsp90/UNC-45
      2. Desmin
         1. aB-Crystalin
   2. Roles
      1. Quality control
      2. Maintainence
      3. AA source
4. Regulation
   1. Growth factor
      1. Atg genes
   2. Energy
      1. AMPK
   3. Nutrient
      1. eIF2alpha

Anotações:

• 1.Synthesised 2. Correctly folded 3. Assembled stoichiometrically (Hsp90) 4. Interact in a spatiotemporal manner

1. Dynamic remodelling
   1. Mechanical
   2. Metabolic