IMMUNOLOGY

IMMUNOLOGY

> Not a specific organ/tissue
Various cell working collectively defend against pathogens
The Components
1. Cadiovascular system
  1. Heart,blood vessels
2. MPS (Mononuclear Phagocyte System)
  1. Reticular fibres
  2. Phagocytes (esp:macrophages)
3. Lymphatic system
  1. Organ of lymphatic system
  2. Primary lymphoid organs
    1. Production site of immune cells
    2. Maturation site for Immune w/o antigen
    3. Eg: Bone marrow, thymus
  3. 2ndary Lymphoid organs
    Anotações:
    - site where immune cell will encounter+bind w/ antigen -> fully matured -> antigen specific effector
    1. Maturation site for immune cell w/ antigen
    2. Eg: Adenoid, tonsils, lymph nodes, spleen, MALT
      Anotações:
      - MALT (Mucosa-Associated Lymphoid Tissue
  4. lymph circulatory system
    1. Lymphatic vessels
Cells of the immune system
1. Differences btwn leukocytes and platelets
Lines of defences
1. 3rd
  1. Adaptive immune response
2. Innate immune response
  1. 1st
    1. External physical barriers
  2. 2nd
    1. Create hostile env.
    2. Fever
      1. Initiate by pyrogens
        change setting in hypothalamus
      2. Benefit
        Reduce iron availability
        Inhibit microbial replication
        Increase immune rxn metabolic rates
    3. Inflammation
      1. Symptoms: Redness,heat,pain,oedema
    4. Phagocytosis
      1. Phagocytes: macrophages, neutrophils
    5. Antimicrobial protiens
      1. The complement system
      2. interferons
      3. iron-binding protein
      4. Antimicrobial peptide
  3. non-specific, response magnitude are similar every encounters

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	Criado por Qurratu Aini mais de 8 anos atrás