central monoamines

Descrição

Neuroscience of Pain Mapa Mental sobre central monoamines, criado por Cher Bachar em 21-04-2013.
Cher Bachar
Mapa Mental por Cher Bachar, atualizado more than 1 year ago
Cher Bachar
Criado por Cher Bachar mais de 11 anos atrás
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Resumo de Recurso

central monoamines
  1. serotonin
    1. Regulation of nociception
      1. endogenous analgesia
        1. Role of 5-HT1 agonists in migrane
        2. Anatomical and functional organisation
          1. RVM
            1. serotonin neurons= NEUTRAL cells
            2. Receptors
              1. 5-HT1
                1. inhibit nociception
                2. 5-HT2/3
                  1. facilitate nociception
                  2. 5-HT7
                    1. periphery-pronociceptive
                      1. spinal cord-antinociceptive
                3. Noradrenaline
                  1. Regulation of nociception
                    1. Anatomical and functional organisation
                      1. NA neurons
                        1. 7 groups in the brainstem

                          Anotações:

                          • A1-A7
                          1. Adrenoceptors
                            1. At spinal level
                              1. Alpha1

                                Anotações:

                                • excitatory via phospholipase C- increased PI and DAG
                                1. Alpha2

                                  Anotações:

                                  • inhibition of adenylyl cyclase- decrease cAMP- like opiod receptors>> main focus because they mimic opiods
                                  1. Beta

                                    Anotações:

                                    • excitation via increase cAMP
                                  2. Phrmacology
                                    1. intrathecal drugs

                                      Anotações:

                                      • injected in the CSF of the spinal cord
                                      1. allpha-adrenoceptor anta
                                        1. blocks Locus coereleus (LC) evoked analgesia
                                          1. blocks PAG/RVM evoked analgesia
                                          2. NA agonists
                                            1. via alpha2 receptors
                                              1. in rats
                                                1. in humans
                                                  1. analgesic effects
                                                  2. side effects
                                                    1. hypotension
                                                      1. sedation
                                              2. Activation
                                                1. electrical or chemical
                                                  1. LC, A7- antinociceptive
                                                2. Descending NA control
                                                  1. Methods
                                                    1. Animals
                                                      1. stimulation of pontine N
                                                        1. electrical
                                                          1. chemical
                                                          2. recording LC neurons
                                                            1. Lesions
                                                              1. electrical of LC
                                                                1. chemical
                                                                2. antagonists
                                                                  1. alpha1/2
                                                                  2. knockouts of alpha2 receptors
                                                                    1. Vital targeting
                                                                    2. Humans
                                                                      1. alpha agonists
                                                                        1. NA re-uptake inhibitors
                                                                      2. Role
                                                                        1. inflammatory pain
                                                                          1. neuropathic pain
                                                                            1. endogenous analgesia

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