530357
Interferons
- Function
- Induction of cellular resistance to Viral Attack
- Regulates most aspects of immune function
- Growth & Differentiation of many cell types
- Sustenance of early phases of pregnancy
- Induction of cellular resistance to Viral Attack
- Classes
- Alpha
- 2 classes- Type1(15) & Type 2(1)
- Type 1 =166 amino acids
- Type 2= 172 amino acids
- Type 1 =166 amino acids
- Glycolylation: post translational modification carbohydrate linkage
- O- Linkage binding only to Serine(S) & Tyrosine(Y)
- N- Linkage Binding only to Asparagine(N)
- rich in leucine & glutamic acid & display conserved cysteines.These generally form 2 disulfide bonds in mature molecule
- O- Linkage binding only to Serine(S) & Tyrosine(Y)
- 2 classes- Type1(15) & Type 2(1)
- Beta
- Gama
- Alpha
- Receptors
- Gama type 2 Receptor
- Signal Transduction
- Cell types that display Gama Receptor Haematopoietic cells(Blood cell types)
- Transmembrane glycoproteins(molecular mass 50kDa and appear as homodimer
- Extracellular gama binding site consists of 200 amino acids folded into 2 homologous
domains
- It also requires second transmembrane glycoprotein( accessory factor 1) that interacts with the extracellular region
- It also requires second transmembrane glycoprotein( accessory factor 1) that interacts with the extracellular region
- Jak-Stat
- (1)Ligand induces receptor dimerisation
- (2)JAK induces reciprocal tyrosine phosphorylation of JAKs associated withthe receptors cytoplasmic tail
- (3)Phosphorylated JAKs phosphorylate tyrosine residues within the receptors cytoplasmic tail used as a docking site for STAT
- (4) This phosphorylation Induces dimerisation of STAT.Dimerised STAT Translocates to the nucleus where it binds to Specific DNA RESPONSE ELEMENTS
- (4) This phosphorylation Induces dimerisation of STAT.Dimerised STAT Translocates to the nucleus where it binds to Specific DNA RESPONSE ELEMENTS
- (3)Phosphorylated JAKs phosphorylate tyrosine residues within the receptors cytoplasmic tail used as a docking site for STAT
- (2)JAK induces reciprocal tyrosine phosphorylation of JAKs associated withthe receptors cytoplasmic tail
- (1)Ligand induces receptor dimerisation
- Cell types that display Gama Receptor Haematopoietic cells(Blood cell types)
- Gama type 2 Receptor
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