Serotonin is released into
synapse from one neuron.
Targets receptor cells on
the receiving neuron at
receptor sites and
afterwards is re-absorbed
by the initial neuron
sending the message.
In order to increases serotonin
at the synapse and increases
stimulation to receiving
neuron, the re-uptake is
inhibited
Anti anxiety's
(Benzodiazepines)
Xanax, valium
and librium
Slow activity of CNS by enhancing the
activity of GABA (gamma-aminobutyric
acid) a neurotransmitter which has a
quietening effect on the neurons in the
brain
Reacts with GABA
receptors on receiving
neurons which opens a
channel allowing a flow
of chloride ions into the
neuron
Chloride makes it harder
for the neuron to be
stimulated by other NT's,
slowing its activity and
creating a relaxed
feeling.
Tricyclic's
Primarily used for OCD
rather than
depression
Block the transporter
mechanism that re-absorbs
serotonin and noradrenaline
into the pre-synaptic cell
after it has fired.
More NT's are left in
synapse, prolonging
their activity and
easing transmission
into next impulse
Target more than 1 NT
Bad side effects, i.e.
hallucinations so are
used only when SSRI's
fail
D - Cycloserine is used to
treat anxiety and
possibly OCD. Is an
antibiotic for TB.
Enhances GABA
transmission
Side effects
Sometimes outweigh
the benefits of the
drug
Insomnia,
hallucinations,
aggressiveness can be
overwhelming and
worse than the OCD
behaviours they're
aiming to combat.
Sometimes are bearable
due to the drug having a
positive impact on
symptoms
I.e. slight dizziness
and nausea
outweigh OCD
behaviours like
cleaning hands
until bleeding
Not lasting cure
Only help to ease
symptoms rather than
actually curing the
behaviour in the first
place
Likely to
relapse in
weeks after
stopping
medication
Effectiveness
Drug trials show that drugs are
effective in treating OCD