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Drug discovery
Descrição
Advanced Molecular Biology & Biotechnology Mapa Mental sobre Drug discovery, criado por Abbey Roberts em 18-02-2014.
Sem etiquetas
advanced molecular biology & biotechnology
advanced molecular biology & biotechnology
Mapa Mental por
Abbey Roberts
, atualizado more than 1 year ago
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Criado por
Abbey Roberts
mais de 10 anos atrás
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Resumo de Recurso
Drug discovery
drugs can have many definitions
substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication
any biological or chemical substance (synthetic or non-synthetic)
anything that affects the way an organism works
can be taken to enhance function
there are many key points
target can be a specific cell type, protein or molecule
are administrated to patients (individuals who have the disease)
ways of measuring
can measure the disease
can measure the effect of the drug
cell death/growth
changes in levels
Pharmacogenomics/Pharmacogenetics
impact on drug discovery and development
How do we get drugs to work?
target validation is key
proteins target have many domains/motifs which each has a different function
domains can localise proteins
domains can bind to other proteins
domains can bind to other molecules
most proteins have multiple domains
proteins have many functions
How drugs are discovered?
disease is anything that can affect the proper functioning of a body
infection
genetic disorder
result of environmental conditions (malnourishment, poisoning, stress)
most of the work in our body is done by proteins
contains thousands of types of proteins
construction of each is determined by the DNA in the nucleus of each cell
DNA contains instruction of how to build a specific protein
How drugs are developed?
Non-clinical drug development
stages in drug discovery process
animal testing
Problem of one vs several chemical
Drugs and plants
Differences and similarities of drugs and medicinal plants
there are many plant based medicines and drugs
need for consumer education about herbal supplements and drugs
different boards and committees
FDA
Institutional Review Board
drug discovery is anything but cheap
company mainly wants value whereas Contract Research Organisations mainly want good understanding of chemistry and competitive price
most drugs fail after considerable expense
failure at Phase 3 could loose company 10% of share value
successful drug could cost between £100 million to over £1 billion from discovery phase to market
increases company share value
money comes from customers and drives future drug discovery
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