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IMMUNISATION OF CARIES
- VACCINATION AGAINST S.MUTANS
- BOWEN 1969: Injected live strain of S.mutans IV to monkeys
- they were then fed a cariogenic diet
- After 1yr: control - 38 cavities+13 early lesions
- Vaccinated - 6 cavities+4 early lesions
- 2nd EXPERIMENT: broken cells of S.mutans injected into oral mucosa
- Control- 64 cavities
- Vaccinated - 0 cavities
- Vaccinated - 0 cavities
- Control- 64 cavities
- 2nd EXPERIMENT: broken cells of S.mutans injected into oral mucosa
- Vaccinated - 6 cavities+4 early lesions
- After 1yr: control - 38 cavities+13 early lesions
- they were then fed a cariogenic diet
- BOWEN 1969: Injected live strain of S.mutans IV to monkeys
- RAT STUDIES
- S.mutans administered via subcutaneous inoculation
- this induced salivary sIgA
- they were then inoculated with the bacteria, reduced level bacteria recovered
- Hence reduced carious lesions
- Hence reduced carious lesions
- they were then inoculated with the bacteria, reduced level bacteria recovered
- this induced salivary sIgA
- S.mutans administered via subcutaneous inoculation
- ANTIGEN OF S.MUTANS
- Protein antigen I/II
- Glucosyltranferase - accumulation
- Glucen binding proteins - phase III
- Lehner 1980 - monkey experiments
- Lehner 1980 - monkey experiments
- Glucen binding proteins - phase III
- Glucosyltranferase - accumulation
- Protein antigen I/II
- Enter text here
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