Post- thrombotic Syndrome -
ulceration and infection
Thrombus
Virchow's Triad
Embolism
Chronic Venous Insufficiency
Superior Vena Cava Syndrome
(SVCS)
Diseases of the Arteries
Aneurysm
True
Fusiform-
circumferential
Saccular- sac
False
Dissecting
Peripheral vascular
diseases
Thromboangitis
obliterans aka Buerger
Disease
inflammation --> necrotizing
Raynaud
Phenomenon and
Disease
vasospasm of the
hands
Peripheral Artery Disease (PAD)
Atherosclerosis
Pathophysiology: Inflammatory
mechanisms in the setting up of
dyslipidemia--> atherosclerosis
1. Endothelial injury &
dysfunction; 2. Fatty Streak; 3.
Fibrotic Plaque; 4. Complicated
lesion/ plaque
Coronary Artery Disease (CAD)
CAN LEAD TO.....
Reversible myocardial ischemia
Stable Angina
Acute Coronary Syndrome (ACS)
Unstable Angina
MYOCARDIAL INFARCTION
STEMI
Thrombus lodges permanently;
Infarction extends through myocardial
wall; ST segment elevation; Highest risk
for serious complications
Non- STEMI
Thomrbus may have broken up
before significant distal necrosis
occurred; subendocardial; usually ST
depression and T wave inversion;
recurrent thrombus formation on
plaque likely to occur w/o intervention
Congesitve Heart Failure
GENERAL: Increased diastolic
(filllling) pressures or inc. diastolic
volume. Not enough getting out.
Risk factors: CAD, HTN (high
afterload, vasoconstricted)
Left sided heart failure
SYSTOLIC
decreased ejection fraction- (normal ejection is
50-75%) this is because there is dec.
contractility - causes inc. preload and inc.
afterload i- which causes dec. contractility -
viscious cycle
DIASTOLIC
dec. filling of the LV - Why would this happen?
Ventricle is stiff - dec. compliance, doesn't stretch
well (due to HTN, remodeling, cardiomyopathy), so
it doesn't fill well. leads to dec. preload. this may
be OK at rest but when you exercise your heart
won't be able to handle it
SEQUELAE _ blood backs up, causes blood to back up into the
lungs - Pulmonary Edema; stasis of bllodd in left chamber
because it's not pumping well; inadequate perfusion of tissues
Right sided heart failure
LEFT SIDED FAILURE
COR PULMOARE
SEQUELAE - fluid backup in the
body
Dysrhythmias
ATRIAL
SINUS
VENTRICULAR
AV
BLOCK
Disorders of the Heart Wall
Pericardum
Acute
pericarditis
Idiopathic
Pericardial
effusion
Accumulation of
pressure in right heart
Constrictive
pericarditis
TB, cancer radiation, cardiac
surgery - calcification and scarring
Myocardium:
Cardiomyopathies
Dilated
Hypertrophic
Restrictive
Endocaridum
Vallvular
Dysfunction
Stenosis or Flapping in the Wind;
both stenosis and regurgitation lead
to inc. workload