Kathleen Jackson
Quiz por , criado more than 1 year ago

Nursing Quiz sobre 1807NRS Safe Administration of Medications 2, criado por Kathleen Jackson em 01-10-2017.

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Kathleen Jackson
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1807NRS Safe Administration of Medications 2

1807NRS Safe Administration of Medications 2

Questão 1 de 30

1

Pharmacodynamics involves the study of following EXCEPT:

Selecione uma das seguintes:

  • Biological and therapeutic effects of drugs

  • Absorption and distribution of drugs

  • Mechanisms of drug action

  • Drug interactions

Explicação

Questão 2 de 30

1

Pharmacodynamics involves the study of following?

Selecione uma das seguintes:

  • Mechanisms of drug action

  • Biotransformation of drugs in the organism

  • Distribution of drugs in the organism

  • Excretion of drug from the organism

Explicação

Questão 3 de 30

1

Pharmacodynamics involves the following?

Selecione uma das seguintes:

  • Information about main mechanisms of drug absorption

  • Information about unwanted effects

  • Information about biological barriers

  • Information about excretion of a drug from the organism

Explicação

Questão 4 de 30

1

Pick out the answer which is the most appropriate to the term “receptor”

Selecione uma das seguintes:

  • All types of ion channels modulated by a drug

  • Enzymes of oxidizing-reducing reactions activated by a drug

  • Active macromolecular components of a cell or an organism which a drug molecule has to combine with in order to elicit its specific effect

  • Carriers activated by a drug

Explicação

Questão 5 de 30

1

What does “affinity” mean?

Selecione uma das seguintes:

  • A measure of how tightly a drug binds to plasma proteins

  • A measure of how tightly a drug binds to a receptor

  • A measure of inhibiting potency of a drug

  • A measure of bioavailability of a drug

Explicação

Questão 6 de 30

1

Target proteins which a drug molecule binds are:

Selecione uma das seguintes:

  • Only receptors

  • Only ion channels

  • Only carriers

  • All answers are correct

Explicação

Questão 7 de 30

1

An agonist is a substance that:

Selecione uma das seguintes:

  • Interacts with the receptor without producing any effect

  • Interacts with the receptor and initiates changes in cell function, producing various effects

  • Increases concentration of another substance to produce effect

  • Interacts with plasma proteins and doesn’t produce any effect

Explicação

Questão 8 de 30

1

If an agonist can produce maximal effects and has high efficacy it’s called:

Selecione uma das seguintes:

  • Partial agonist

  • Antagonist

  • Agonist-antagonist

  • Full agonist

Explicação

Questão 9 de 30

1

If an agonist can produce submaximal effects and has moderate efficacy it’s called:

Selecione uma das seguintes:

  • Partial agonist

  • Antagonist

  • Agonist-antagonist

  • Full agonist

Explicação

Questão 10 de 30

1

An antagonist is a substance that:

Selecione uma das seguintes:

  • Binds to the receptors and initiates changes in cell function, producing maximal effect

  • Binds to the receptors and initiates changes in cell function, producing submaximal effect

  • Interacts with plasma proteins and doesn’t produce any effect

  • Binds to the receptors without directly altering their functions

Explicação

Questão 11 de 30

1

A competitive antagonist is a substance that:

Selecione uma das seguintes:

  • Interacts with receptors and produces submaximal effect

  • Binds to the same receptor site and progressively inhibits the agonist response

  • Binds to the nonspecific sites of tissue

  • Binds to one receptor subtype as an agonist and to another as an antagonist

Explicação

Questão 12 de 30

1

The substance binding to one receptor subtype as an agonist and to another as an antagonist is called:

Selecione uma das seguintes:

  • Competitive antagonist

  • Irreversible antagonist

  • Agonist-antagonist

  • Partial agonist

Explicação

Questão 13 de 30

1

Irreversible interaction of an antagonist with a receptor is due to:

Selecione uma das seguintes:

  • Ionic bonds

  • Hydrogen bonds

  • Covalent bonds

  • All answers are correct

Explicação

Questão 14 de 30

1

Mechanisms of transmembrane signaling are the following EXCEPT:

Selecione uma das seguintes:

  • Transmembrane receptors that bind and stimulate a protein tyrosine kinase

  • Gene replacement by the introduction of a therapeutic gene to correct a genetic effect

  • Ligand-gated ion channels that can be induced to open or close by binding a ligand

  • Transmembrane receptor protein that stimulates a GTP-binding signal transducer protein (G-protein) which in turn generates an intracellular second messenger

Explicação

Questão 15 de 30

1

Tick the second messenger of G-protein-coupled (metabotropic) receptor:

Selecione uma das seguintes:

  • Adenylyl cyclase

  • Sodium ions

  • Phospholipase C

  • cAMP

Explicação

Questão 16 de 30

1

Tick the substance which changes the activity of an effector element but doesn’t belong to second messengers:

Selecione uma das seguintes:

  • cAMP

  • cGMP

  • G–protein

  • Calcium ions

Explicação

Questão 17 de 30

1

Give the definition for a therapeutical dose:

Selecione uma das seguintes:

  • The amount of a substance to produce the minimal biological effect

  • The amount of a substance to produce effects hazardous for an organism

  • The amount of a substance to produce the required effect in most patients

  • The amount of a substance to accelerate an increase of concentration of medicine in an organism

Explicação

Questão 18 de 30

1

Pick out the correct definition of a toxic dose:

Selecione uma das seguintes:

  • The amount of substance to produce the minimal biological effect

  • The amount of substance to produce effects hazardous for an organism

  • The amount of substance to produce the necessary effect in most of patients

  • The amount of substance to fast creation of high concentration of medicine in an organism

Explicação

Questão 19 de 30

1

Which effect may lead to toxic reactions when a drug is taken continuously or repeatedly?

Selecione uma das seguintes:

  • Refractoriness

  • Cumulative effect

  • Tolerance

  • Tachyphylaxis

Explicação

Questão 20 de 30

1

What term is used to describe a decrease in responsiveness to a drug which develops in a few minutes?

Selecione uma das seguintes:

  • Refractoriness

  • Cumulative effect

  • Tolerance

  • Tachyphylaxis

Explicação

Questão 21 de 30

1

Idiosyncratic reaction of a drug is:

Selecione uma das seguintes:

  • A type of hypersensitivity reaction

  • A type of drug antagonism

  • Unpredictable, inherent, qualitatively abnormal reaction to a drug

  • Quantitatively exaggerated response

Explicação

Questão 22 de 30

1

Characteristic unwanted reaction which isn’t related to a dose or to a pharmacodynamic property of a drug is called:

Selecione uma das seguintes:

  • Idiosyncrasy

  • Hypersensitivity

  • Tolerance

  • Teratogenic action

Explicação

Questão 23 de 30

1

If two drugs with the same effect, taken together, produce an effect that is equal in magnitude to the sum of the effects of
the drugs given individually, it is called as:

Selecione uma das seguintes:

  • Antagonism

  • Potentiation

  • Additive effect

  • None of the answers are correct

Explicação

Questão 24 de 30

1

What phenomenon can occur in case of using a combination of drugs?

Selecione uma das seguintes:

  • Tolerance

  • Tachyphylaxis

  • Accumulation

  • Synergism

Explicação

Questão 25 de 30

1

What is the type of drug-to-drug interaction which is the result of interaction at receptor, cell, enzyme or organ level?

Selecione uma das seguintes:

  • Pharmacodynamic interaction

  • Physical and chemical interaction

  • Pharmaceutical interaction

  • Pharmacokinetic interaction

Explicação

Questão 26 de 30

1

What is the type of drug-to-drug interaction which is connected with processes of absorption, biotransformation,
distribution and excretion?

Selecione uma das seguintes:

  • Pharmacodynamic interaction

  • Physical and chemical interaction

  • Pharmaceutical interaction

  • Pharmacokinetic interaction

Explicação

Questão 27 de 30

1

The situation when failure to continue administering the drug results in serious psychological and somatic disturbances is called?

Selecione uma das seguintes:

  • Tachyphylaxis

  • Sensibilization

  • Abstinence syndrome

  • Idiosyncrasy

Explicação

Questão 28 de 30

1

Tolerance and drug resistance can be a consequence of:

Selecione uma das seguintes:

  • Drug dependence

  • Increased metabolic degradation

  • Depressed renal drug excretion

  • Activation of a drug after hepatic first-pass

Explicação

Questão 29 de 30

1

Tolerance and drug resistance can be a consequence of:

Selecione uma das seguintes:

  • Change in receptors, loss of them or exhaustion of mediators

  • Increased receptor sensitivity

  • Decreased metabolic degradation

  • Decreased renal tubular secretion

Explicação

Questão 30 de 30

1

Tolerance develops because of:

Selecione uma das seguintes:

  • Diminished absorption

  • Rapid excretion of a drug

  • Both answers are correct

  • No answer is correct

Explicação

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