Autocrine vs paracrine vs endocrine signalling: Autocrine = Acts on ❌; Endocrine = Acts on ❌; Paracrine = Acts on❌;
Fill in the gaps
What does OPG do to RANKL?
Fuck all
Inhibits ligand-binding
Facilitates ligand-binding
What effect does Calcitonin have on Osteoblasts?
Inhibits Osteoblast activity
Ensures their precursor's survival
What effect does Calcitonin have on Osteoclasts?
Inhibits Osteoclast activity
What effect does CSF1 have on Osteoblasts?
Ensures precursor's survival
What effect does CSF1 have on Osteoclasts?
OCN is a hormone involved in the regulation of glucose metabolism, which improves the sensitivity of target organs to insulin, thus improving glucose handling by the body. …and MAYBE stimulates insulin production/secretion. Still, OCN = ??
OsteoCalciN
OsteoCalcitoniN
OCN is the most abundant Non-collagenous protein Mineral Collagenous protein Neurotransmitter Osteokine( Non-collagenous protein, Mineral, Collagenous protein, Neurotransmitter, Osteokine ) in bone.
ADHR = ??
Autosomal Dominant Hypophosphataemic Rickets
Adrenal Dominant Hypophosphataemic Rickets
Autosomal Dominant Hyperphosphataemic Rickets
Adrenal Dominant Hyperphosphataemic Rickets
OOM = ??
Oncogenic OsteoMalacia
Osteogenic OncoMalacia
ADHR and OOM are examples of what?
Phosphate-wasting disorders
Calcium-wasting disorders
Vitamin-D-wasting disorders
Vitamin-K-wasting disorders
Mis-sense mutations in FGF23 Interleukin 6 Interleukin 15 FGF6( FGF23, Interleukin 6, Interleukin 15, FGF6 ) in ADHR patients at a furin consensus cleavage site results in a resistance to proteolysis.
FGF23 regulates Phosphate OPG OCN Calcium Vitamin D( Phosphate, OPG, OCN, Calcium, Vitamin D ) concentrations in plasma. It’s secreted by osteocytes in response to low [above] or High Low( High, Low ) Vitamin D.
FGF23 acts on the kidneys, where it Decreases Increases( Decreases, Increases ) the expression of NPT2 (a Na-PO4 co-transporter in the proximal tubule). This leads to Increased Decreased( Increased, Decreased ) PO4 reabsorption (which results in Increased Decreased( Increased, Decreased ) excretion).
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