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Inactivating mutations in the widely-expressed ( NF1, NF2, HK1, HK2, CPT1, CPT2 ) gene “has a strong association with” ( Congenital Pseudoarthrosis of the Tibia, Congenital Pathology of the Tibia, Calcium-deficient PseudoarThrosis, Congenital Pseudoarthritis of the Tibia, Calcium-deficient PseudoarThritis ) (CPT).