Cholesterol is a 26-Carbon sterol lipid that’s synthesised through a complex 37-step process. It composes 10% 30% 50% 70% 90%( 10%, 30%, 50%, 70%, 90% ) of cell membranes. Circulating cholesterol arises from the diet as well as from Intracellular Extracellular Intercellular( Intracellular, Extracellular, Intercellular ) synthesis. It circulates mostly as Cholesterol Ester (cholesterol + FA).
Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by Increased Decreased( Increased, Decreased ) LDL-Chol HDL-Chol( LDL-Chol, HDL-Chol ) levels. Caused by a loss of LDL-R.
Lysosomal Storage Disease (aka Niemann-Pick disease type C) is a collection of ~50 rare inherited metabolic pathologies. Its hallmark is defective lysosomal function. It’s characterised by Free cholesterol FFA TAG( Free cholesterol, FFA, TAG ) Accumulation Dissipation( Accumulation, Dissipation ) in the lysosome due to the loss of function of NPC1 and/or NPC2.
The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?
Energy
Phospholipids
In cancer, metabolism changes. De Novo Cholesterol Synthesis AND uptake Synthesis Uptake( Synthesis AND uptake, Synthesis, Uptake ) Increases Decreases( Increases, Decreases ); De Novo Lipid Synthesis AND uptake Synthesis Uptake( Synthesis AND uptake, Synthesis, Uptake ) Increases Decreases( Increases, Decreases ).
Prostate cancer growth is [primarily?] driven by ❌. It’s a ❌ metabolism cancer and is greatly dependent on ❌.
CRPC = ??
Castration-Resistant Prostate Cancer
Castratian-Resistant Prostate Cancer
Gene Expression of Steroidogenic Enzymes is Increased Decreased( Increased, Decreased ) in CRPC.
