Question 1. Infection-like process related to assembled Aβ, tau and α-synuclein has the following characteristics
A. Protein misfolding begins in specific regions
B. Pathological assemblies of misfolded protein spread to other areas
C. Prion-like process
D. All of the above
Question 2. The following are the main risk factors for cognitive decline and dementia, except:
A. Traumatic brain injury
B. Obesity and diabetes
C. Hypertension
D. Education
Question 3. In some individuals at early stages of Alzheimer disease there is a:
A. Severe loss of parietal cortical neurons
B. Severe loss of entorihnal cortex neurons
C. Severe loss of occipital cortical neurons
D. Severe loss of all cortical neurons
Question 4. The author of this lecture proposes a glial hypothesis of the origin of normal aging. This hypothesis says that:
A. Synaptic atrophy is driven by astrocyte activation
B. Increase of transcription of GFAP
C. Age impairment of neurite growth reversed by SiRNA diminishing GFAP in old astrocytes
Question 5. Age and Alzheimer changes in amyloidosis and neurodegeneration are related to the presence of the number of copies of a cholesterol transporter :
ApoE4
PS1
APP
PS2
Recent research proposes that aging cortical atrophy is most probably due to:
A. Loss of a huge number of small neurons
B. Neuron schrinkage
C. Loss of large neurons
D. Astrocyte loss
Question 7. Supported by strong evidence we recognize now as main factors to decrease risk of cognitive decline and dementia: (more than one answer possible)
B. Education
C. Being vegetarian
D. Physical activity
A. Moderate Alcohol consumption
Question 8. Normal aging includes the decline of all these processes, except:
A. Eye-blinking conditioning
B. EEG response time auditory response to auditory stimulus
C. Axonal conduction speed
D. Verbal memory
Question 9. During normal aging in the cerebral cortex:
A. Decrease the numbers of astrocytes
B. Decrease the numbers of entorhinal cells
C. Increase the number of astrocytes
D. Increase the number of olygodendrocytes
Question 10. Normal aging of the brain includes: (more than one answer possible)
A. Atrophy of cerebral cortex
B. Fast loss of cognitive of processes
C. Loss of synapses
D. Accumulation of amyloid
Question 11. Which of the following Alzheimer related genes are not involved in familiar early onset of the disease:
D. Chromosome 21 APP gene
C. Chromosome 19 ApoE gene
B. Chromosome 14 PS-1 gene
A. Chromosome 1 PS-2 gene
