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Anticoagulation is initiated with unfractionated or LMW heparin. The initial IV bolus should consist of ( 7,500-10,000 units, 1,000-1,500 IU, 5,000-10,000 units, 10,000-20,000 units ) of unfractionated heparin, then the continuous heparin infusion should be at ( 1,000-1,500 IU, 7,500-10,000 units, 500-1,000 IU, 2,000-3,000 IU ) per hour (IU standing for "international units"). The dosage is calculated to maintain the ( aPTT, PT, INR ) at approximately ( twice, three times ) the normal value. An infusion pump is used to deliver the prescribed dosage.
LMW heparins are increasingly used to prevent and treat venous thrombosis. They do not require the close lab monitoring of unfractionated heparins. These heparins are administered ( subcutaneously, instramuscularly, subdermally ) in fixed doses, QD or BID, which allows outpatient treatment. These types of heparins are also more effective and carry lower risks for ( bleeding and thrombocytopenia, excessive bleeding, excessive menstrual bleeding, thrombocytopenia ).
Warfarin may be initiated with heparin therapy. Overlapping therapy for ( 4-5 days, 4-5 weeks, 4 weeks, 5 weeks ) is important because the full anticoagulant effect of warfarin is delayed, and warfarin may actually promote clotting during the first few days of therapy. Warfarin doses are adjusted to maintain the INR at ( 2.0-3.0, 1.0-2.0, 3.0-4.0, 4.0-5.0 ). Once the INR has been achieved, ( heparin, warfarin ) is discontinued and a maintenance dose of ( warfarin, heparin ) is prescribed.
Anticoagulation will generally be continued for at least ( 3 months, 3 weeks, 6 months, 1 year ). When DVT recurs or risk factors are present, anticoagulant therapy may be prolonged. Regular follow ups are necessary to be sure INR remains within the desirable range.