Fluoroquinoiones are:
Gentamycin
Moxifloxacin
Ciprofloxacin
Levofloxacin
Mechanism of action of quinolones is:
inhibition of protein synthesis
inhibition of cell wall synthesis
inhibition of topoisomerase II and IV
inhibition of DNA transcription and replication
Fluoroquinolones have:
broad antibacterial spectrum
narrow antibacterial spectrum
bacteriostatic effect
bactericidal effect
Point out the correct statements for pharmacokinetics of fluoroquinolones:
bad oral absorption and are administered always parenterally
distribute well into all tissues and body fluids
inhibit some liver cytochromes
most of them are excreted renally
Fluoroquinolones are used for treatment of:
Urinary tract infections
Respiratory infections
Skin infections
Gl infections
Adverse drug reactions of fluoroquinolones are:
articular cartilage erosion (arthropathy)
hypertension
seizures in patients with epilepsy
prolongation of QT interval
Quinolones are contraindicated in
pregnancy and breast-feeding
children under 18 years of age
patients with epilepsy
patients with renal failure
Drug interactions of fluoroquinolones are:
increase serum levels of theophyiline by inhibiting its metabolism
decrease serum levels of theophyiline by inducing its metabolism
synergism with beta-lactams
calcium and other divalent cations decrease their absorption
