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Antimicrobial Agents and Resistance

Questão 1 de 18

1

Penicillin is in which class of antibiotics?

Selecione uma das seguintes:

  • B-lactams

  • Glycopeptides

  • Mannopeptimycins

  • Lantibiotics

Explicação

Questão 2 de 18

1

How have antibiotic developers overcome bacteria that resist B-lactams by preventing them from entering the cell?

Selecione uma das seguintes:

  • Produce membrane pores

  • Conjugate the B-lactam with a membrane transporter

  • Conjugate the B-lactam with a siderophore

Explicação

Questão 3 de 18

1

In which decade was the first glycopeptide discovered?

Selecione uma das seguintes:

  • 1950's

  • 1940's

  • 1960's

  • 1970's

Explicação

Questão 4 de 18

1

Which drug was easier for microbes to develop resistance towards?

Selecione uma das seguintes:

  • B-lactams

  • Vancomycin

Explicação

Questão 5 de 18

1

Are Mur enzyme inhibitors bacteriostatic or bactericidal?

Selecione uma das seguintes:

  • Bacteriocidal

  • Bacteriostatic

Explicação

Questão 6 de 18

1

Reverse transcriptase has poor proofreading activity. What is a consequence of this?

Selecione uma das seguintes:

  • Mutations do not occur as often

  • The viral genome is more likely to integrate permanently into the host genome

  • Mutations arise quickly and could cause antiviral resistance

  • The host cell genomic machinery is hijacked and loses proofreading ability

Explicação

Questão 7 de 18

1

A patient has unprotected sex with someone who is HIV-positive and soon tests positive for HIV. You prescribe AZT and Nelfinavir in combination therapy.

The viral load continues to increase rather than decrease. Based merely on this information, what do you think has occurred?

Selecione uma das seguintes:

  • The HIV has mutated to be resistant to AZT and Nelfinavir in your patient

  • Drug-resistant HIV was transmitted to your patient

Explicação

Questão 8 de 18

1

A patient has unprotected sex with someone who is HIV-positive and soon tests positive for HIV. You prescribe AZT and Nelfinavir in combination therapy.

Your clinical microbiologist tests your patient’s HIV strain and find that it is currently not resistant to the drugs you have prescribed. Rather, your patient was not taking every dose of the antiviral cocktail. What should you, the doctor, do?

Selecione uma das seguintes:

  • Tell the patient to begin taking the original drugs as prescribed

  • Change the prescription in case some viruses have gained mutations that make them resistant to the current drugs

  • Order another drug resistance test in a few weeks

  • Both a and c

  • Both b and c

Explicação

Questão 9 de 18

1

Doxycycline is an Tetracycline antibiotic used to treat a variety of bacterial infections, such as those causing acne, urinary tract infections, eye infections, and gum disease. However, it is imperative that children and pregnant or nursing mothers do not take this drug, as it can cause permanent yellowing/greying of teeth in babies and children.

The tooth discoloration is due to the fact that Tetracyclines can chelate (bind and sequester) the calcium ions needed for normal adult tooth development. Other than calcium, what do Tetracyclines bind to?

Selecione uma das seguintes:

  • 50S ribosomal subunit

  • 30S ribosomal subunit

  • Dihydropteroate synthase

  • DNA helicase

  • RNA polymerase

Explicação

Questão 10 de 18

1

Doxycycline is an Tetracycline antibiotic used to treat a variety of bacterial infections, such as those causing acne, urinary tract infections, eye infections, and gum disease. However, it is imperative that children and pregnant or nursing mothers do not take this drug, as it can cause permanent yellowing/greying of teeth in babies and children.

A pregnant mother has a urinary tract infection. What antibiotic has the same mode of action as Doxycycline but wouldn’t cause the tooth discoloration in her child?

Selecione uma das seguintes:

  • Penicillin

  • Vancomycin

  • Chloramphenicol

  • Quinolone

  • Aminoglycoside

Explicação

Questão 11 de 18

1

Rabies virus has a negative-sense single-stranded RNA genome. It is a neurotropic virus that spreads through saliva.

There is a drug called Favipiravir that is being tested for use against Rabies. What do you think is the mode of action of Favipiravir?

Selecione uma das seguintes:

  • Halt DNA synthesis

  • Halt RNA synthesis

  • Prevent integration into host genome

  • Inhibit reverse transcriptase

Explicação

Questão 12 de 18

1

You have a chronic athlete’s foot infection. Which antifungal cream would be the best choice?

Selecione uma das seguintes:

  • Itraconazole

  • Clotrimazole

  • Griseofulvin

  • Nystatin

  • Amphotericin B

Explicação

Questão 13 de 18

1

Trimethoprim-sulfamethoxaxole is used to treat Shigellosis. What is the mode of action of this Sulfonamide?

Selecione uma das seguintes:

  • Inhibit translation

  • Inhibit nucleotide synthesis

  • Inhibit cell wall biosynthesis

  • Inhibit bacterial adherence to host cell

Explicação

Questão 14 de 18

1

Preencha o espaço em branco para completar o texto.

refers to the ability of an antimicrobial drug to harm the target microbe without harming the host?

Explicação

Questão 15 de 18

1

Preencha o espaço em branco para completar o texto.

In the Kirby-Bauer disk diffusion test, the of the zone of inhibition is measured and used for interpretation.

Explicação

Questão 16 de 18

1

Preencha o espaço em branco para completar o texto.

A scientist discovers that a soil bacterium she has been studying produces an antimicrobial that kills gram-negative bacteria. She isolates and purifies the antimicrobial compound, then chemically converts a chemical side chain to a hydroxyl group. When she tests the antimicrobial properties of this new version, she finds that this antimicrobial drug can now also kill gram-positive bacteria. The new antimicrobial drug with broad-spectrum activity is considered to be .

Explicação

Questão 17 de 18

1

Which clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug?

Selecione uma das seguintes:

  • treatment of a polymicrobic mixed infection in the intestine

  • prophylaxis against infection after a surgical procedure

  • treatment of strep throat caused by culture identified Streptococcus pyogenes

  • empiric therapy of pneumonia while waiting for culture results

Explicação

Questão 18 de 18

1

Narrow-spectrum antimicrobials are commonly used for prophylaxis following surgery.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

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