The anterior-most part of the PFS is Brodman area 10 4 6 8( 10, 4, 6, 8 ), also called anterior PFC or frontal-poler cortex.
It is enlarged smaller( enlarged, smaller ) in humans.

The orbitofrontal ventrolateral dorsolateral( orbitofrontal, ventrolateral, dorsolateral ) cortex is involved in the bottom-up response to reward cues, the anticipation of rewards and the reaction to them.

The PFC might play a role in top-down self-regulation but this is controversial and the exact mechanism is most likely more distributed.