Mer Scott
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PHCY310 Quiz sobre L35,36,37 CKD Pharmacology, Therapeutics, Labs, criado por Mer Scott em 16-04-2019.

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L35,36,37 CKD Pharmacology, Therapeutics, Labs

Questão 1 de 13

1

Three determinants of renin release:
1. Decreased sensed by kidney
2. Decreased BP or renal
3. receptor activation

Arraste e solte para completar o texto.

    Na+ concentration
    blood flow
    Beta 2

Explicação

Questão 2 de 13

1

Angiotensin causes profound vasoconstriction and aldosterone release.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 3 de 13

1

Both ACEIs and ARBS will decrease systemic vascular resistance and increase renal perfusion.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 4 de 13

1

Diuretics for CKD:
1. Loop diuretics inhibit the activity of the Na-K-2Cl symporter in the . Therefore maximum
effect is ~%.
2. Thiazide diuretics inhibit the activity of the Na-Cl symporter in the . Maximum effect is ~%.
3. K-sparing diuretics inhibit the activity of epithelial Na+ channels in the . Maximum effect is ~%.
4. Aldosterone antagonists competitively inhibit the binding of to the mineralocorticoid receptor. The only class of diuretics that do not enter the tubule cell from the apical () side, and instead from the basolateral () side.

Arraste e solte para completar o texto.

    thick ascending loop of Henle
    20-25
    distal tubule
    5
    late distal tubule and collecting duct
    2
    aldosterone
    blood
    tubular

Explicação

Questão 5 de 13

1

Classification of CKD:
• Normal/ CKD 1: GFR >90 mL/min
• Mild/ CKD 2: GFR mL/min
• Moderate/ CKD 3: GFR mL/min
• Severe/ CKD 4: GFR mL/min
• End-stage/ CKD 5: GFR <15 mL/min

Arraste e solte para completar o texto.

    60-90
    30-60
    15-30

Explicação

Questão 6 de 13

1

Non-pharmacological treatment of CKD entails dietary sodium restriction, and protein restriction if GFR < 30mL/min.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 7 de 13

1

When using ACEIs and ARBs in CKD the target is a reduction in urine of 30-50%. Starting can GFR; start at a dose and titrate the dose slowly to effect. Other Important side effects to consider:
kalaemia
renal impairment
• Dry cough (fairly )
• Angioedema (, but serious)

Arraste e solte para completar o texto.

    albumin
    reduce
    low
    Hyper
    Acute
    common
    rare

Explicação

Questão 8 de 13

1

Methods of estimating renal function:
1. Creatinine-based methods (CLcr, eGFR)
• Collection of 24 hour urine samples ( clearance)
• Cockcroft-Gault (an estimate of creatinine clearance)
• MDRD
• CKD-EPI
All these are reported by the lab as “”.
2. Cystatin C clearance
3. Clearance of a : Inulin (NOT insulin), 51Cr EDTA (radioisotope)

Arraste e solte para completar o texto.

    creatinine
    Equation
    eGFR
    xenobiotic

Explicação

Questão 9 de 13

1

Creatinine is freely filtered by the glomerulus and so its clearance lets us estimate GFR.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 10 de 13

1

Cockcroft & Gault equation:
CLcr = ( (140 - ) x x K* ) /

* K = 1.23 for males, 1.04 for females

Arraste e solte para completar o texto.

    age
    ideal body weight
    serum creatinine

Explicação

Questão 11 de 13

1

All creatinine-based methods;
• Are poor predictors of GFR if malnourished or low mass
• Over-estimate GFR in the elderly, (using total body weight), severe or end-stage renal disease
• Not for < years old
• Unreliable when renal function rapidly (acute renal failure)
• Drugs tubular secretion can raise creatinine conc (e.g. probenecid, trimethoprim, spironolactone)

Arraste e solte para completar o texto.

    muscle
    18
    changing
    obese
    inhibiting

Explicação

Questão 12 de 13

1

In CKD, K+ secretion is resulting in accumulation. Concentrations above mmol/L become symptomatic. Hyperkalaemia is more likely to be observed in CKD 4 or 5, and is exacerbated by and K-sparing diuretics.

Arraste e solte para completar o texto.

    reduced
    5.5-6
    ACE-I, ARBs

Explicação

Questão 13 de 13

1

Match the ranges.
- Creatinine (plasma): Adult male: 50- µmol/L, Adult female: 45- µmol/L
- Urea (plasma): Adults: mmol/L
- Sodium (plasma) mmol/L
- Osmolality (plasma) 280- mmol/kg
- Osmolality (urine) 300- mmol/kg

Arraste e solte para completar o texto.

    110
    90
    3.2-7.7
    135-145
    300
    1200

Explicação