All creatinine-based methods;
• Are poor predictors of GFR if malnourished or low ❌ mass
• Over-estimate GFR in the elderly, ❌ (using total body weight), severe or end-stage renal disease
• Not for <❌ years old
• Unreliable when renal function ❌ rapidly (acute renal failure)
• Drugs ❌ tubular secretion can raise creatinine conc (e.g. probenecid, trimethoprim, spironolactone)
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