These cells contain a nucleus divided into 2–5 lobes. They are a type of phagocyte and are normally found in the bloodstream. They migrate through the blood vessels, then through interstitial tissue, following chemical signals such as Interleukin-8 (IL-8) in a process called chemotaxis. They are the predominant cells in pus, accounting for its whitish/yellowish appearance. They are recruited to the site of injury within minutes following trauma, and are the hallmark of acute inflammation.
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