Mer Scott
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PHCY320 (Oncology) Quiz sobre ON2 Cancer pathogenesis, criado por Mer Scott em 05-10-2019.

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ON2 Cancer pathogenesis

Questão 1 de 11

1

Oncogenesis is the mechanism by which a tumor arises, involving DNA . If the DNA is not repaired, the cell will
continue to and 'fix' the mutation in place. Successive mutations can build up until the cell division is no longer regulated.

Arraste e solte para completar o texto.

    mutation
    divide

Explicação

Questão 2 de 11

1

Oncogenesis:
• 1 mutation is not enough, need mutations
• Number of mutations varies – impacts on
• These should generally be picked up at the points, and the DNA repaired, unless the checkpoint itself is mutated (‘’ mutation)…

Arraste e solte para completar o texto.

    multiple
    immunogenicity & prognosis
    check
    driver

Explicação

Questão 3 de 11

1

Which of these is not an origin of mutations?

Selecione uma das seguintes:

  • DNA replication

  • Inherited

  • Environmental insult

  • Infectious agents

  • GMOs

Explicação

Questão 4 de 11

1

DNA replication
• normal DNA replication introduces 1 mutation /10^7 nucleotides
• most mutations still cause cancer, however there are some gene families in which a mutation can lead to oncogenesis:
- tumor suppressor genes( in cancer): factors & growth regulators, repair & genes, contact inhibition genes
- activator genes (oncogenes & proto-oncogenes, in cancer): angiogenic genes – eg growth factor (VEGF), genes which allow metastasis and escape from surveillance

Arraste e solte para completar o texto.

    won’t
    key
    inactive
    apoptosis
    growth
    active
    vascular endothelial
    immune

Explicação

Questão 5 de 11

1

Inherited mutations
• some forms of cancer have a higher occurrence in some families
• they have inherited either:
- defective genes
- activated

BRCA is a tumor gene involved in repairing DNA . BRCA1/2 mutation results is a 56–84% lifetime risk of developing cancer and an 36–63% risk for cancer.

Arraste e solte para completar o texto.

    tumor suppressor
    oncogenes
    suppressor
    damage
    breast
    ovarian

Explicação

Questão 6 de 11

1

Environmental Insult:
• Chemical = carcinogens. Either damage DNA or their damage DNA. Types of damage are strand , gene , nucleotide deletions & substitutions. Most common chemically induced cancer - lung cancer (% of all cancer deaths).
• Physical = radiation – variable toxicity.
Non-ionizing:
• UV, microwaves.
• UV causes
Ionizing:
• X-rays, g-rays, atomic bombs, nuclear reactors
tumor development (thyroid, breast, bone marrow)

Arraste e solte para completar o texto.

    directly
    metabolites
    breakage
    truncation
    30
    melanoma
    Spontaneous

Explicação

Questão 7 de 11

1

Human Papillomavirus Viruses (HPV) is an infectious agent that can cause cancer. HPV is isolated from > 90% of tumors. HPV also causes carcinoma. High risk’ cancer-causing types:
- HPV- (55% of tumors)
- HPV-18 (15%)
- HPV-45 (10%)

Arraste e solte para completar o texto.

    cervical
    anogenital and oropharnygeal
    16

Explicação

Questão 8 de 11

1

The immune system has pro-tumor effects - chronic inflammation has been associated with oncogenesis, and anti-tumor effects - immune system can kill cancer cells.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 9 de 11

1

CD8 T cells must be activated by a professional (APC) to kill cancerous cells. The problem is we need to get activation of the APC, but there is no infection. Hopefully there is enough and/or cell to activate the APC.
The immune response should kill tumours but tumors are tissues. CD8 T cells are not allowed to destroy cells expressing self . The solution is an immune response directed against: antigens (new proteins in genetically unstable cells), viral proteins, or antigens.

Arraste e solte para completar o texto.

    antigen presenting cell
    necrosis
    stress
    cytotoxic
    self
    antigens
    mutated
    inappropriately expressed

Explicação

Questão 10 de 11

1

Which of these is NOT an immune evasion strategy used by tumours?

Selecione uma das seguintes:

  • not make any tumor antigens

  • shut down antigen presentation

  • shut down MHC class I expression

  • shut down expression of co-stimulator or adhesion molecules

  • not make immune cells

Explicação

Questão 11 de 11

1

Tumor is immunosuppressive.
• Tumour expresses molecules eg Fas L
• Tumour secretes anti-inflammatory or suppressive molecules eg TGFb,

Arraste e solte para completar o texto.

    T cell apoptosis
    IL-10, PGE-2

Explicação