Environmental Insult:
• Chemical = carcinogens. Either ❌ damage DNA or their ❌ damage DNA. Types of damage are strand ❌, gene ❌, nucleotide deletions & substitutions. Most common chemically induced cancer - lung cancer (❌% of all cancer deaths).
• Physical = radiation – variable toxicity.
Non-ionizing:
• UV, microwaves.
• UV causes ❌
Ionizing:
• X-rays, g-rays, atomic bombs, nuclear reactors
• ❌ tumor development (thyroid, breast, bone marrow)
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