Mitotic inhibitors which are ❌ derivatives are cell cycle-specific.
1. Vinca alkaloids
e.g. Vincristine, vinblastine, vindesine, vinorelbine
Bind to ❌, inhibits polymerisation (mitosis). Eliminated via metabolism. Given ❌ usually. Toxicity: constipation, BMS usually dose limiting (absent for ❌), dose-limiting ❌ for vincristine, neuropathy (mixed motor/sensory), paraesthesia, loss of deep reflexes (axonal transport).
2. Taxanes
e.g. Docetaxel, paclitaxel
Stabilise ❌ structure, prevent cell division. Poor ❌ absorbtion. Hepatic metabolism. Toxicity: Dose-limiting ❌, arthralgia/myalgia syndrome (mechanism unknown)
Paclitaxel: ❌ neuropathy (motor at higher dose)
Docetaxel: leg ❌ (fluid retention – peripheral effect)
Arraste e solte para completar o texto.
neurotoxicity
neurotoxicity
neutropaenia
neutropaenia