Oestrogen receptor antagonists e.g. Tamoxifen, clomiphene citrate, nafoxidine
- ❌ estrogen receptor modulators (SERM)
- ❌ binds to oestrogen receptors
• Oestrogenic effects (inhibit ❌ resorption, stimulates ❌ synthesis)
• Anti-oestrogenic effects (breast tissue, inhibits synthesis of ❌)
Example: Tamoxifen, for ❌ breast cancer. Is an adjuvant/❌. Metabolised by CYP2D6, 3A4, metabolites have ❌ t1/2. Unwanted Effects: ❌ flushes, nausea, amenorrhoea, ❌ bleeding
Arraste e solte para completar o texto.
Competitively
Competitively
recurrent metastatic
recurrent metastatic