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Hyperammonaemia is caused by an impaired conversion of to . This can be caused by liver failure, for example in viral , c or other toxins. This can also be caused by genetic defects, for example causing mutations in the enzymes involved in the .
The symptoms of this include irratibility, headache and vomiting. In more severe cases hyperammonaemia can result in encephalopathy, seizures and ataxia.