Fechar
Anthracyclines drugs are
Describe "steal liposomal"
merit of "steal liposomal"
Anthracyclines SEs + solutions (1)
Lifetime doses of Anthracyclines.
1. Doxorubicin: -----?
2. Daunorubicin: -----?
3. Epirubicin: -------?
Anthracyclines SEs + solutions (2)
Treatment for anthracycline IV extravasates are .....
What is the difference btw
1. Dexrazoxane (Zinecard®)
2. Dexrazoxane (Totect®)
Alkylating Agent is
Cyclophosphamide is closely related to ----?
cyclophosphamide requires activation by CYP450 to have an anticancer effect, the primary isoforms are -----?
What is the name of the metabolite formed by cyclophosphamide wh/ causes hemorrhagic cystitis?
The therapeutic, DNA reactive metabolite is of cyclophosphamide is ----?
acrolein is a ------?
1. Due to bladder toxicity, -------- is necessary with either IV or PO administration of cyclophosphamide.
2. During high-dose treatment, patients should receive vigorous IV -------?
AEs of cyclophosphamides
Taxanes drugs are ----
Taxanes MOA
Why do patients receive dexamethasone with docetaxel?
What are the major toxicities associated with paclitaxel and docetaxel?
Why do patients receive premedication with dexamethasone, diphenhydramine and an H2 antagonist prior to paclitaxel?
Microtubule inhibitors are
Microtubule inhibitors MOA
Ixabepilone (epithilone) is associated with -----?
Ixabepilone BBW includes ------?
Cremophor (also used as an excipient in
taxane formulations) is known to be a --------- and may lead to ----------- which can be life threatening if not treated appropriately
Cremophol EL requires ---------- as premeds
What is the purpose of Cremophor® EL in taxane and microtubulin inhibitors formulations?
vinorelbine (Navelbine®) is used for ---?
Antimetabolites
Capecitabine is available in tablets form as ------------- prodrug?
Capecitabine is an elegant drug in that it allows for -------- concentrations of --------- (the active product provided by 5-FU) in cancerous cells than in normal cells.
Activation of 5-FU through several steps to yield a metabolite which targets thymidylate synthase and acts as a suicide inhibitor is an MOA of -------------- drugs?
Capecitabine SEs are ----- ?
How do you identify drug leakage caused by “hand-and-foot syndrome”?
capecitabine carries a black box warning
of a -------?
Antibodies (moAb) that TARGETS HER2/neu and HER2(+)
Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) MOA ---?
Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) SEs are -----?
Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) BBW is ----?
What are pretreatment drug recommendations for Trastuzumab (Herceptin®) and pertuzumab (Perjeta®) in other to avoid infusion related toxicitity?
What is the difference btw Trastuzumab (Herceptin®) and Ado-trastuzumab emtansine (Kadcyla™)
Ado-trastuzumab emtansine (Kadcyla™) BBW includes ----?
DM1 is associated with
Fam-trastuzumab deruxtecan-nxki (Enhertu®) indication is -----?
Fam-trastuzumab deruxtecan-nxki (Enhertu®) MOA?
Fam-trastuzumab deruxtecan-nxki (Enhertu®) AES
Kinase Inhibitors are
Lapatinib and Neratinib MOA?
Lapatinib and Neratinib AEs ---?
Lapatinib (Only) SEs ---?
Lapatinib BBW
Lapatinib indication ---?
Neratinib (Nerlynx®) indication ----?
