Antimicrobial Agents

Ludwig's Angina

Anti-Infection
Agents

Antibacterial
Agent

Antibiotics

Antimicrobials

Concept of Selective Toxicity

Mechanisms of Selective Toxicity

Unique Drug Targets

Selective Inhibition

Common Targets

Mechanisms of
Antibacterial Action

Abx which affect
Cell Wall Synthesis

Abx that act on Protein Synthesis

Abx that act on
Nucleic Acid Synthesis

Inhibition of Cell Wall Synthesis

Alterations in Cell Membrane

Inhibition of Protein Synthesis

Inhibition of Nucleic Acid Synthesis

Inhibition of Folic Acid Synthesis

Microbial Resistance

Natural Resistance

Acquired Resistane

Enzyme Inactivation

Genetic Mechanisms

Intensity to apoptosis

Superinfections

Antibiotic Therapy

Chemoprophylaxis

Spectrum of Activity

Antibiotic Failure

Bactericidal Bacteriostatic

Antibiotic Adverse Effects

Penicillins

Parenteral Penicillin G/
Oral Penicillin V

Penicillins

Antistaphylococcal Penicillins

Penicillins

Aminopenicillins

Penicillins

Ureidopenicillins

Penicillins

Mechanism of action

Penicillin G (Benzylpenicillin)

Penicillins ADRx

Penicillin Allergy

Penicillin Allergy

Penicillin Anaphylaxis

Penicillins-Drug Interactions

Aminopenicillins

[Ampicillin, Amoxicillin,
Bacampicillin]

Betalactamases: Penicillinase

Penicillin + Beta-lactamase
Inhibitor

Cephalosporins

Cephalosporins

Third Generation Cephalosporins

Fourth Generation
Cephalosporins

Fifth Generation Cephalosporins

Cephalosporins
Adverse Effects

Protein Synthesis Inhibitors

Protein Synthesis Inhibitors

Tetracycline

Macrolides: Erythromycin

Newer Macrolides

Telithromycin

Chloramhenicol

Clindamycin (Cleocin)

Clindamycin ADRx

Pseudomembranous Colitis

Sulfonamides:
Sulfamethoxazole

Bacteriostatic

Sulfonamides-Adverse Effects

Trimethoprim

Bactrim, Septra, Cotrim,
Co-trimoxazole

Nucleic Acid Synthesis Inhibitors

Metronidazole
Adverse Effects

Metronidazole Drug Interactions

Fluoroquinolones

Ciprofloxacin, Norfoxacin,
Levofloxacin

Fluoroquinolones

Ciprofloxacin

What Abx would you use on a
woman during her first
trimester of pregnancy?

Aminoglycosides

Aminoglycosides

Side Effects

MRSA

Methicillin resistant
Staph aureus

VRE

Vancomycin Resistant
Enterococci

VRSA

Vancomycin Resistant
S aureus

STreptogramins

Oxazolidinones

Pleuromutilins