Pharm II Exam III practice quiz

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Which of the following is NOT a cardinal sign of inflammation?

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Inflammation ends with permanent destruction of tissue or with complete healing after removal of injurious stimulus

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Chronic inflammation is beneficial

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Cell damage results in the release of

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A fundamental feature of inflammation is

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Which of the following is NOT a goal of treatment of inflammation?

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Which of the following is NOT considered a drug treatment of arthritis?

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Which of the following is true about NSAIDS?

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Which of the following is best against release of arachidonic acid?

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Which of the following is NOT a physiologic effect of COX-1?

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Choose ALL of the following that can be seen in OA

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Which best describes Osteoarthritis?

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Prevalence of OA increased due to aging population and obesity

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Which of the following is NOT a radiographic finding of OA?

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OA is overtreated

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Which of the following would NOT be effective to treat nociceptive and inflammatory pain syndromes?

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Which of the following would NOT be effective in treating neuropathic and functional pain syndromes?

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Nociceptive and inflammatory pain are both adaptive (protective)

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OA pain mechanisms are unknown

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Which of the following is NOT a method of pain management in OA?

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Which of the following is TRUE regarding acetominophen?

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95% of Acetaminophen is conjugated into NAPQ1, a toxic metabolite

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Why does chronic ingestion of ethanol increase risk of hepatotoxicity?

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Why is acetylcysteine used as an antidote for acetaminophen toxicity?

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How do NSAIDs block the COX protein?

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Which of the following is NOT possible from the use of NSAIDs?

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Which of the following is true regarding -oxicam like drugs

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Which of the following is a possible side effect of -oxicam like drugs when taken for a long period of time?

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Fenamate derivatves are used for severe dysmenorrhea

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Which of the following is NOT true regarding Indomethicin?

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Which of the following best describes the mechanism of Indomethacin?

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Which of the following is true regarding ASA?

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Reye's syndrome develops in children who suffer a bacterial infection

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Mr. Smith is a 70 year old male with history of inflammatory GI and gastric ulcers. You would like to prescribe NSAIDs to treat his OA. Which of the following drugs could you also co-prescribe to avoid worsening his other pre-existing conditions?

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What advantage does Sulindac have over any other NSAID?

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Long-term NSAID analgesic medication is perfectly acceptable in patients with history of CV disease

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Which of the following drugs is MOST appropriate for a nursing mother?

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Why does ASA interact with antihypertensives?

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Why should you not use SSRIs in combination with NSAIDs?

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The use of anticoagulants and ________ has caused reported fatal hemorrhages

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Choose ALL of the following drugs whose renal clearance is reduced due to use of ASAs and NSAIDS

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High ASA dose can inhibit the metabolism of which drug?

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Which of the following drugs should be avoided in patients with sulfa allergy (according to Foong, not Chand)?

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Celecoxib is metabolized by CYP 2D6

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Which of the following drugs does NOT interact with COX-2 inhibitors?

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Which of the following is NOT an adverse effect of COX-2 inhibitors?

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Celecoxib and Ibuprofen are overall similar, except for cost, GI effects, and bleeding time effects

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High carb diet can decrease absorption of acetominophen

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SSRIs are more effective than TCAs as adjuvant analgesics

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How can you delay absorption of ASA?

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Under normal conditions, which of the following prevents platelet aggregation?

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Phospholipase A2 is activated by which of the following?

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Which of the following medications can lower the seizure threshold?

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Which of the following is NOT a substrate of CYP2D6?

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Which of the following is NOT a clinical use of Naltrexone?

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Which of the following is NOT true regarding tramadol?

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Which of the following is NOT true regarding opioids with mixed mechanisms?

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Which of the following is NOT an indication for use of opioids with mixed mechanisms?

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OA primarily attacks the joints but also skn, lungs, vessels and muscles

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Rheumatoid arthritis, along with bacterial endocarditis and SLE, is found to have elevated levels of autoantibodies against

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Rheumatoid can occur at any age

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Which of the following is NOT a goal of treating RA

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Successful treatment of RA is seen with when ________ are started immediately

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What is the role of glucocorticoids in RA

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Newer biologic DMARDs are known to

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Which of the following DMARDs is a folic acid analogue that may also increase adenosine levels?

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Which of the following drugs requires monthly monitoring of CBC, liver, and renal function

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Use of methotrexate increases risk of hepatotoxicity with fibrosis and cirrhosis

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Which of the following DMARDs blocks synthesis of UMP, thus reducing B and T cell populations?

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Leflunomide is currently used for

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Cholestyramine can be given to clear hydroxychloroquine from the system quickly

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How does Hydroxychloroquine work against RA?

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Which drug causes the least toxicity?

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Which of the following is NOT an adverse effect of hydroxychloroquine?

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Which of the following is a mechanism of Minocycline

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Which of the following is NOT true regarding Chrysotherapy?

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Which of the following is true regarding the use of cyclophosphamide in the use of RA?

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Each of the following is a mechanism of penicillamine except

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Monitoring the CBC and liver enzymes is necessary when taking which drug?

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Which of the following is NOT a common side effect of penicillamine?

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Which of the following is NOT a disadvantage when using biological DMARDs?

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Biological DMARDs are not recommended until at least one non-biological DMARD has been administered without sufficient success

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Which of the following is FALSE regarding TNF inhibitors such as Entanercept?

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Which of the following is true regarding rituximab?

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Rituximab depletes B lymphocytes by apoptosis

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Which of the following best describes the mechanism of abatacept?

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Abatacept cannot be used as monotherapy but can be used combination with other DMARDS

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Which of the following is best described as "unique" and caused by deposition of urate crystals in joints

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Which of the following is NOT one of the four stages of gout?

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Which of the following would not be used for gout

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Colchicine can be used in low doses as prophylaxis for acute attacks of gout

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Colchicine can be taken continuously at high doses

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Colchicine limits the inflammatory response by which of the following mechanisms?

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Which drug shares the same mechanism as Allopurinol?

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Why can't allopurinol be used for monotherapy?

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Which of the following is NOT an adverse effect of Allopurinol?

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Which of the following is NOT true regarding Probenecid

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Febuxostat requires dose adjustment during renal insufficiency

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Which of the following gout medications could also be useful in a patient with hypertension

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Which of the following has a similar mechanism to Probenecid but should be used with caution in patients taking anticoagulants?

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Which of the following is NOT true regarding SLE?

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There is a prevalence of SLE in women. One possible reason for this is because

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Increased levels of erythrocyte sedimentation rate is specific to SLE

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For treatment of SLE, we should NOT use drugs with

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Corticosteroids can cause muscle wasting

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What is a concern with abruptly withdrawing corticosteroids?

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Which of the following is NOT true regarding the use of hydroxychloroquine?

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What leads to the formation of PGE2 and PGI2?

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Which of the following does NOT use a voltage-gated calcium channel?

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Which of the following is NOT a common mediator in peripheral sensitization?

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For peripheral sensitization, which of the following is NOT used to target analgesia?

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Which of the following does NOT contribute to central sensitization?

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L-NAME can be used to inhibit NOS which prevents further retrograde stimulation of glutamate release

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Which ion is usually associated with NMDA in its inactive state ?

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Which of the following inhibits the dissociation of Mg from the NMDA receptor, thus preventing activation?

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Which of the following is NOT a mechanism of opioids?

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Which of the following opioid receptors does NOT mediate the main pharmacological effects of opiates?

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Which opioid receptor subunit is responsible for most of the analgesic effects along with some unwanted effects?

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Opioid receptor activation is G-coupled

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Select ALL of the strong opiods

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Select ALL of the pure opioid agonists

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Opiod pure agonists have a higher affinity for_________ receptors.

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Pentazocine is an antagonist at the _ receptor, but a partial agonist at the ___ receptor.

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Most mixed mechanism opioids cause

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Which peripherally acting opioid antagonist can be used to reduce post-op ileus and opioid-induced constipation?

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Opioids have a ceiling effect

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Which of the following does NOT have a 90% first pass effect?

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Which of the following receptors does codeine activate?

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How is morphine excreted?

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How is codeine excreted?

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Which of the following is true?

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Codeine does not cause tolerance over prolonged use

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Which of the following is an alternative to codeine when a weak opiod is required?

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Which of the following is an alternative to codeine when a strong opiod is required?

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Which of the following is equipotent to morphine but has greater oral efficacy?

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Which of the following is used to treat opioid addiction?

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Which of the following opioids can prolong QT interval

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Methadone has a long duration and therefore can be given has a single dose daily

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It is better to give meperidine orally rather than IV because it decreases risk of anxiety and other CNS side effects

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Which of the following is correct, starting with the least potent to the most potent

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Which of the following is NOT true regarding fentanyl?

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