Loss of WT-1 gene results in what cancer?
Neuroblastoma
Wilms tumor
All of the following are Autosomal recessive cancer predisposition disorders except?
Xeroderma Pigmentosum (XP)
Bloom syndrome
Fanconi anemia
Ataxia Telengiectasia
Breast cancer associated with BRCA2
All of the following are features of fanconi anemia except
Pancytopenia (bone marrow failure)
Risk of AML
Upper limb skeletal abnormalities
DNA repair defect
none of the above
Glioblastoma multiforme is due to 100x expression of an miRNA true or false?
Translocation in Burkitt's lymphoma
8:14
9:22
11:22
All of the following are true statements except
Kaposis sarcoma caused by HHV-8
Non-Hodgkin lymphoma - EBV
Cervical cancer - HPV
T-Cell leukemia - HTLV-I retrovirus
CML - HPV
HPV oncogenes E6 & E7 act by?
inactivating p53 thereby activating cell proliferation
activating P21 Transciption
In which cells telomeres are renewed (by activation of telomerase)?
Germ cells
cancer cells
all of the above
None of the above
Replicative senescence is due to the absence of telomerase - true or false
TERC : reverse transcriptase and TERT : RNA template true or false
Upregulation of what gene upregulates telomerase
MYC
ABL
BCR
RET
Telomerase reactivation in cancer is the initiating event true or false
Telomerase reactivation in cancer is an important step in cancer progression true or false
Which of the following receptors belong to RTK family (receptor tyrosine kinases)
GFR
Insulin receptor
both
Activated RTKs phosphorylate what effector proteins?
PLC
PI3K
both PLC PI3K
Adenylate cyclase
RTK activation -> reveals docking site for adapter protein GRB2 -> binds to SOS (RAS GEF) --> activates RAS -> activates MAPK --> activates TFs ( FOS, JUN, MYC) true or false
Her2/EGFR2 genes are amplified in 30% breast cancers true or false
RAS-Gap gene codes for neurofibromin (NF1) true or false
Estrogen receptor = Transcription factor which binds to estrogen response element enhancing transcription of cyclin D true or false
Tamoxifen is an estrogen receptor antagonist true or false
Prostate cancer occurs in the transition zone and BPH occurs primarily in the peripheral zone true or false
Flutamide and bicalutamide are androgen receptor antagonists true or false
