Regarding HIV infection all of the following are true except
It is retrovirus that infects CD4 T cells, dendritic cells and macrophages and binds to gp120
gp 120 changes conformation and binds co-receptors CCR5 and CXCR4
Reverse transcriptase copies viral ssRNA genomes into ds cDNA
Replication of HIV occurs in activated T and B cells
A genetic deficiency of the co-receptor CCR5 confers resistance to HIV infection in vivo
All of the following are seen in a typical course of HIV infection except
Infected CD4 cells die as a result of viral replication
There is a latent viral reservoir in the lymphoid tissue
gp 120 expressed on infected cell binds CD4 on uninfected cell and they fuse forming multinucleated giant cells in HIV infected brain
Opportunistic infections will begin to arise when CD4 T cell count goes below 400 cell/cubic mm
You need 2 positive ELISA and a confirmatory positive Western Blot to confirm HIV positive status
All of the following are true about HIV drugs except?
Block CCR5 - will block fusion
Block Reverse Transcriptase - Blocks integration
Block maturation (gp 160 -> gp41)
HAART (Highly Active Anti-retroviral Therapy) = 1 NRTIs + a PI/NNRTI/II
