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Assessment 1.3 Nan Days

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Ass 1.3. Nan

Questão 1 de 58

1

Which of the following is NOT an advantage of solution dosage form as compared to solid dosage form?

Selecione uma das seguintes:

  • Greater Bioavailability

  • Ease of Transportation

  • Ease of Administration

  • Pediatric Use

Explicação

Questão 2 de 58

1

Which of the following is true with regards to the solubility of a weak acid?

Selecione uma das seguintes:

  • Solubility increases with decreasing pH

  • Solubility increases with increasing pH

  • Solubility decreases with increasing pH

  • Solubility remains constant with increasing pH

Explicação

Questão 3 de 58

1

A novel compound dissolves in water and the solution becomes cold. Which of the following will further increase the solubility of this compound in water?

Selecione uma das seguintes:

  • Decrease in temperature

  • Decreased amount of water

  • Increase in temperature

  • Increased amount of novel compound

Explicação

Questão 4 de 58

1

__________ are dispersions of liquid drugs in liquid vehicles.

Selecione uma das seguintes:

  • Suspension

  • Emulsion

  • Colloid

  • Gel

Explicação

Questão 5 de 58

1

Which of the following has the least aqueous solubility

Selecione uma das seguintes:

  • CHCl3

  • CCl4

  • CH2Cl2

  • CH3Cl

Explicação

Questão 6 de 58

1

Syrup is a concentrated alcoholic solution with sweetener and medicinal agent ?

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 7 de 58

1

Which of the following is not an example of Cosolvent system?

Selecione uma das seguintes:

  • Aromatic Elixir

  • Iodine Tincture

  • Acacia Syrup

  • Paregoric tincture

Explicação

Questão 8 de 58

1

All of the following are advantages of Pharmaceutical solutions EXCEPT

Selecione uma das seguintes:

  • Easier to swallow

  • Greater Bioavailability

  • More stable than solid dosage forms

  • Homogenous uniform dosing is possible

Explicação

Questão 9 de 58

1

The two MAJOR factors affecting solubility are?

Selecione uma das seguintes:

  • Temperature and agitation

  • pH and particle size

  • Polarity and agitation

  • Temperature and pH

Explicação

Questão 10 de 58

1

To determine the ratio of buffer components to add to a solution to maintain a given pH you should use which equation?

Selecione uma das seguintes:

  • pH= pKa + log (salt/acid)

  • pHmax = pKa + Log [(St-Sa)/Sa]

  • B= change in B/ change in pH

  • St= Sa(1+ [Ka/H])

Explicação

Questão 11 de 58

1

All of the following are generally true about Organic Compound Solubility EXCEPT:

Selecione uma das seguintes:

  • More carbon atoms decrease the aqueous solubility

  • Halogens decrease solubility

  • Polar groups increase solubility

  • Low melting point indicates low solubility

Explicação

Questão 12 de 58

1

Which of the following would be considered an ethanol/ water cosolvent system.

Selecione uma das seguintes:

  • Inverted syrup

  • Magic Mouthwash

  • Paregoric

  • Acacia Syrup

Explicação

Questão 13 de 58

1

Which of the following is an example of a cosolvent?

Selecione uma das seguintes:

  • Sodium Acetate

  • Oleic Acid

  • Sodium Benzoate

  • Saccharin Sodium

Explicação

Questão 14 de 58

1

which of the following is NOT a force of attraction that affects dissolution?

Selecione uma das seguintes:

  • Ion-dipole

  • Van Der Waals

  • Hydrogen Bonding

  • Ionic Bonding

Explicação

Questão 15 de 58

1

Sedimentation increases with_______?

Selecione uma das seguintes:

  • Particle size reduction

  • Increase in viscosity of dispersion medium

  • Increase in density of dispersed phase

  • Increase in density of dispersion medium

Explicação

Questão 16 de 58

1

Which of the following is true when particle aize of an antibiotic powder is reduced from 50 micrometers to 5 micrometers?

Selecione uma das seguintes:

  • Higher surface area, Lower surface energy

  • Lower surface area,Higher surface energy

  • Lower surface area, Lower surface energy

  • Higher surface area, higher surface energy

Explicação

Questão 17 de 58

1

Flocculation occurs due to stronger forces of attraction between the particles of a suspension.

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 18 de 58

1

The Sedimentation Volume (F) for an ideal flocculated system is

Selecione uma das seguintes:

  • 0.5

  • 1.0

  • 0.7

  • 0.3

Explicação

Questão 19 de 58

1

Which of the following is responsible for charge on a neutral particle surface when suspended in water?

Selecione uma das seguintes:

  • Adsorption of OH-

  • Adsorption of H2O

  • Particle wetting

  • Particle agglomeration

Explicação

Questão 20 de 58

1

In an electrical double layer which layer is associated with the zeta potential?

Selecione uma das seguintes:

  • Bulk layer

  • Diffuse layer

  • Surface layer

  • Stern layer

Explicação

Questão 21 de 58

1

Which of the following situations best represents a deflocculated system?

Selecione uma das seguintes:

  • F=0.2

  • F=0.9

  • F=1.0

  • F=1.2

Explicação

Questão 22 de 58

1

Flocculation is observed at extreme (+)ve and (-)ve values of zeta potential.

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 23 de 58

1

The structured vehicle approach is applicable to both flocculated and deflocculated particles.

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 24 de 58

1

Which of the following best represents the flow of flocculated suspension?

Selecione uma das seguintes:

  • Newtonian Flow

  • Dilant Flow

  • Plastic Flow

  • Pseudoplastic Flow

Explicação

Questão 25 de 58

1

In which of the following methods oil and emulsifier are mixed first followed by addition of water at once?

Selecione uma das seguintes:

  • In-situ soap method

  • English Method

  • Auxiliary Method

  • Continental Method

  • Bottle Method

Explicação

Questão 26 de 58

1

Skin permeation is a must for the component(s) of both medicated and non-medicated topical dosage forms.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 27 de 58

1

A major skin permeation pathway for small hydrophilic molecule is?

Selecione uma das seguintes:

  • Trans appendageal

  • Hair Follices

  • Transcellular

  • Intercellular

Explicação

Questão 28 de 58

1

Absorption bases are associated with all of the following except?

Selecione uma das seguintes:

  • Anhydrous

  • Absorb water

  • Water Washable

  • Hydrous

  • Occlusive

Explicação

Questão 29 de 58

1

What is HFA?

Selecione uma das seguintes:

  • Hydroflouroalkane

  • Hydroflorine Association

  • How Far Away

  • Happy Friend Association

Explicação

Questão 30 de 58

1

Droplets decelerate as they leave the spray nozzle of a pressurized spray.

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 31 de 58

1

pDMIs can be sprayed in any orientation

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 32 de 58

1

All medical Aerosol products contain a propellant

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 33 de 58

1

All nasal sprays deliver the same dose independent of the orientation in which they are used

Selecione uma das seguintes:

  • True

  • False

Explicação

Questão 34 de 58

1

Which of the following is NOT an advantage of a topical antibiotic sprayed on the skin rather than delivered by a cream.

Selecione uma das seguintes:

  • Convenient

  • Minimal contamination of unused product

  • Accurate dose metering

  • No need to touch skin

  • Smaller particle size

Explicação

Questão 35 de 58

1

If inhaled, particles with a diameter of 6 micrometers would be expected to penetrate the respiratory system to the level of the:

Selecione uma das seguintes:

  • Bronchioles

  • Alveoli

  • Nasal Cavity

  • Throat (pharynx)

Explicação

Questão 36 de 58

1

For which type(s) of aerosol system(s) will the pressure drop as the product is used?

Selecione uma das seguintes:

  • Compressed gas system

  • Three- phase system

  • Two-Phase system

  • B and C only

Explicação

Questão 37 de 58

1

Which part of the valve assembly of an aerosol is responsible for preventing leakage of the formulation from the container?

Selecione uma das seguintes:

  • Mounting Cap

  • Actuator

  • Gasket

  • Housing

Explicação

Questão 38 de 58

1

Which of the following is NOT an example of a "surface Spray" aerosol?

Selecione uma das seguintes:

  • Dermatological aerosols

  • Paint Sprays

  • Hair Sprays

  • Room deodorizers

Explicação

Questão 39 de 58

1

What is the FDA recommended alcohol content limit in liquid OTC drug product for children 6-12 years?

Selecione uma das seguintes:

  • 10%

  • 1%

  • 0.5%

  • 5%

Explicação

Questão 40 de 58

1

Which of the following descriptive terms of relative solubility includes 12.5% w/v strength?

Selecione uma das seguintes:

  • Very soluble

  • Soluble

  • Slightly soluble

  • Freely Soluble

Explicação

Questão 41 de 58

1

Which of the following groups on organic molecules will NOT increase water solubility?

Selecione uma das seguintes:

  • CH2F

  • NH2

  • COOH

  • SO3H

Explicação

Questão 42 de 58

1

Which of the following is the pharmaceutical advantage of elixirs over syrups as liquid dosage forms?

Selecione uma das seguintes:

  • Contains less sugar

  • Dissolve ionized and unionized drugs

  • Provide faster drug absorption

  • Are better at masking the taste of drugs

Explicação

Questão 43 de 58

1

Which of the following minimum alcohol percentages is required in medicated syrups to prevent microbial growth?

Selecione uma das seguintes:

  • 5%

  • 0.1%

  • 15%

  • 1%

Explicação

Questão 44 de 58

1

Water cannot dissolve which of the following organic compounds by intermolecular hydrogen bonds?

Selecione uma das seguintes:

  • Esters

  • Alcohol

  • Acids

  • Hydrocarbons

Explicação

Questão 45 de 58

1

Besides accurately and conveniently measuring dosage volume which of the following factors is important when making drug solutions for oral administration?

Selecione uma das seguintes:

  • Color

  • Bioavailability

  • Stability

  • Taste

Explicação

Questão 46 de 58

1

Which of the following is an example of an ingredient in an organogel?

Selecione uma das seguintes:

  • Sodium alginate

  • Hydrocarbon waxes

  • Polyethylene glycol

  • Carboxylmethylcellulose

Explicação

Questão 47 de 58

1

Which of the following describes the action of a flocculating agent in drug suspensions?

Selecione uma das seguintes:

  • Enable loose interparticle attraction

  • Dissolve the suspended particles

  • Prevent interparticle attraction

  • Reduce the particle size

Explicação

Questão 48 de 58

1

Which of the following is a correct statement regarding inhalation drug products (aerosols)?

Selecione uma das seguintes:

  • Each successive dose is slightly smaller as the pressure decreases with each actuation.

  • The total quantity of accurate dose from a metered dose inhaler is limited by depletion of the liquid phase of the propellant

  • The total quantity of accurate doses from a metered dose inhaler is limited by depletion of the active drug.

  • chlorofluorocarbon are federally prohibited for use as propellants

Explicação

Questão 49 de 58

1

Which of the following blends of surfactants would favor a stable O/W emulsion?

Selecione uma das seguintes:

  • 0.5 parts Myrj 45 + 0.5 parts Brij 30

  • 0.4 parts Span40 +0.6 parts Tween 20

  • 0.6 parts span60 +0.4 parts Tween80

  • 0.7 parts span80 + 0.3 parts Tween60

Explicação

Questão 50 de 58

1

Which of the following terms describes a fluid drug preparation that would increasingly flow more freely as it is agitated?

Selecione uma das seguintes:

  • Pseudoplastic

  • Plastic

  • Dilant

  • Thixotropic

Explicação

Questão 51 de 58

1

Stoke's Law equation does NOT include which of the following factors?

Selecione uma das seguintes:

  • Interparticle Attraction

  • Fluid Density

  • Particle Diameter

  • Gravitational Constant

Explicação

Questão 52 de 58

1

When treating a topical condition, all of the following are suitable criteria for selecting an ointment base for drug delivery EXCEPT:

Selecione uma das seguintes:

  • Degree of Occlusion provided

  • Therapeutic systemic blood levels of drug

  • Stability of drug in an ointment base

  • Characteristics of the skin that will be treated.

Explicação

Questão 53 de 58

1

Which of the following is an example of a water soluble base

Selecione uma das seguintes:

  • White ointment USP

  • Lanolin USP

  • Polyehtylene Glycol Ointment USP

  • Hydrophillic Ointment USP

Explicação

Questão 54 de 58

1

Which of the following is NOT an appropriate pharmacist counseling point to a patient before applying ophthalmic ointment?

Selecione uma das seguintes:

  • Tip of the tube should be placed in gentle contact with the conjunctival sac

  • Patient should wash and dry hands before application

  • Improperly handled ophthalmic products can lead to eye infection

  • After application blurred vision is normal and will likely occur

Explicação

Questão 55 de 58

1

Which of the following is FALSE regarding levigating agents which are used to reduce drug particle size?

Selecione uma das seguintes:

  • Glycerin is an appropriate levigating agent for O/W bases

  • The levigating agent must be physically and chemically compatible with the drug and the ointment base

  • The drug for levigation should be soluble in the liquid used as the levegating agent

  • Mineral oil is a good levigating agent for W/O ointment bases

Explicação

Questão 56 de 58

1

Which of the following TDDS products is permitted to be cut into smaller pieces for patient specific therapy?

Selecione uma das seguintes:

  • Nitro-Dur

  • Nicoderm

  • Duragesic

  • Fentanyl Patch

  • All of the above

  • None of the above

Explicação

Questão 57 de 58

1

All of the following factors predict favorable transdermal drug absorption for systemic therapy EXCEPT:

Selecione uma das seguintes:

  • Full hydration of stratum corneum

  • A high aqueous solubility of the drug

  • Molecular weight of drug of about 100-400

  • A high partition coefficient of the drug

Explicação

Questão 58 de 58

1

Wearing a TDDS for longer than the approved duration can result in unsafe plasma drug concentration

Selecione uma das seguintes:

  • True

  • False

Explicação

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