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Which of the following are pharmacologic properties of antipsychotic drugs? a. They block the dopamine receptor b. They affect the hypothalamic temperature regulation system c. They cause emesis d. They are synergistic with LSD e. They cause hypertension
a) (a) and (b) only
b) (a), (b) and (c)
c) (b), (c) and (d)
d) (c), (d) and (e)
e) (d) and (e) only
The antipsychotic effects of the phenothiazines are probably the result of
a. Release of serotonin in the brain
b. Release of norepinephrine in the brain
c. Blockade of dopaminergic sites in the brain
d. Prevention of the release of norepinephrine from brain neuron terminals
e. Increase in the dopamine content of the cerebral cortex
The antipsychotic effects of phenothiazines result from
d. An increase in the dopamine content of the cerebral cortex
e. Prevention of the release of norepinephrine from brain neuron terminals
Chlorpromazine and related drugs are thought at act by blocking which of the following receptors?
a. Adrenergic
b. Muscarinic
c. Dopaminergic
d. Central serotonin
Which of the following is an irreversible side-effect resulting from longterm administration of phenothiazines?
a. Sedation
b. Xerostomia
c. Infertility
d. Parkinsonism
e. Tardive dyskinesia
Tardive dyskinesia is a neurological side-effect of which of the following classes of drugs?
a. Alcohols
b. Tricyclic antidepressants
c. Barbiturate antiepileptics
d. Phenothiazine antipsychotics
e. Monoamine oxidase inhibitors
Which of the following drugs are most likely to cause extrapyramidal\ stimulation?
a. Antibiotics
b. Salicylates
c. Barbiturates
d. Phenothiazines
e. Benzodiazepines
Phenothiazine derivatives do NOT produce
a. Jaundice
c. Gingival hyperplasia
d. Postural hypotension
e. Symptoms of parkinsonism
All of the following actions are associated with the use of chlorpromazine EXCEPT:
b. Photosensitivity
c. Excessive salivation
d. Anticholinergic effects
e. Antiadrenergic effects
The drug most commonly used to treat severe mental depression is
a. Sodium
b. Imipramine
c. Chlorpromazine
d. Tranylcypromine
e. Dextroamphetamine
Which of the following drugs is most effective as an antidepressant?
a. Diazepam
b. Reserpine
c. Amitriptyline
d. Chlorpromazine
e. Hydroxyzine
Which of the following is most likely to be the major mechanism of action of the tricyclic antidepressants?
a. Enhanced release of acetylcholine
b. Inhibition of neuronal synthesis of norepinephrine
c. Potentiation of serotonin synthesis in nervous tissue
d. Stimulation of reuptake of norepinephrine from the synaptic cleft
e. Blockade of the reuptake of amine neurotransmitters released into the synaptic cleft
Tricyclic antidepressants have a prominent side effect that most nearly resembles the usual pharmacological action of
a. Codeine
b. Atropine
c. Ephedrine
d. Propranolol
e. Methacholine
Which of the following drugs has its primary use in the treatment of the manic phase of depressive psychosis?
a. Lithium
c. Imipramine
d. Amphetamine
e. Chlorpromazine
Lithium carbonate is particularly effective in treating
a. Parkinsonism
b. Hypertension
c. Schizophrenia
d. Acute anxiety
e. Manic-depressive psychosis
The current drug of choice for treatment of the manic phase of manic-depressive psychosis is
b. Caffeine
c. Reserpine
d. Imipramine
e. Amphetamine