Ifeoma Okekearu
Quiz por , criado more than 1 year ago

KUSOP Pharmacology III "Sample Questions"

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Ifeoma Okekearu
Criado por Ifeoma Okekearu aproximadamente 9 anos atrás
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Neuro Pharmacology - Depression and Anxiety

Questão 1 de 15

1

Activation of the thalamus can activate the innate fear pathway. Without the collaboration of the prefrontal cortex, this activation can lead to fear manifestations without a source.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 2 de 15

1

Which of the following statements about the manifestation of anxiety/fear symptoms is not true?

Selecione uma das seguintes:

  • Lesions of the medical prefrontal cortex increases the risk for anxiety.

  • Inhibition of the orbitofrontal cortex leads to the hyperactivity of the amygdala in the presence of a potential threat which produces fear responses.

  • In the innate fear response, the thalamus is activated by the amygdala with sequential prefrontal cortex activation leading to the fear manifestation.

  • The amygdala mediates key functions in the processing of fear and threat-related information.

Explicação

Questão 3 de 15

1

Select all of the options that are effective in the treatment of anxiety disorder

Selecione uma ou mais das seguintes:

  • Relaxation Training

  • Systematic Desensitization

  • Group Therapy

  • Pharmacotherapy

Explicação

Questão 4 de 15

1

Select the statements about the tuberomamillary nucleus that are true

Selecione uma ou mais das seguintes:

  • It is inhibited by GABA from the ventrolateral pre optic area.

  • It is activated by glutamate

  • It is inhibited by orexin

  • Histamine promotes calm wakefulness through H2 receptors

Explicação

Questão 5 de 15

1

Where to benzodiazepines bind and what is their mechanism of action?

Selecione uma das seguintes:

  • They bind to a niche between the α and γ subunits of the GABAa receptors behaving as GABA agonist

  • They bing to the niche between the α and γ subunits of the GABAb receptors acting as a positive allosteric modulator

  • They bind to a niche between the α and γ subunits of the GABAa receptors behaving as positive allosteric modulators

  • They bing to the niche between the α and γ subunits of the GABAb receptors acting as a GABA agonist

Explicação

Questão 6 de 15

1

Positive modulation of the GABAa receptors of the amygdala will produce a hypnotic effect

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 7 de 15

1

Flumenazil is a GABA antaagonist

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 8 de 15

1

Which anti-xiolitic(s) would be a good choice for an elderly patient?

Selecione uma ou mais das seguintes:

  • Lorazepam

  • Temazepam

  • Diazepam

  • Chlordiazepoxide

Explicação

Questão 9 de 15

1

Drugs binding to α1, α2, α3, α5, and γ subunits of the GABAa synaptic receptor mediate phasic inhibition triggered by peak concentrations of GABA predisposing users to dependence.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 10 de 15

1

What is the recommended rate of reduction for people wanting to discontinue the use of benzodiazepines?

Selecione uma das seguintes:

  • Stop immediately and drink a lot of water

  • Flumenazil injections over the course of 5-7 days

  • Decrease by 10 percent each day

  • None of the above responses are correct

Explicação

Questão 11 de 15

1

Barbiturates produce an anti-xiolitic effect by binding to the β subunit of the GABA-a receptor. At high concentrations, they can mimic GABA and directly activate chloride channels.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 12 de 15

1

Overdose of barbiturates can lead to death due to respiratory and cardiac depression and the lack of an effective antagonist.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 13 de 15

1

Monoamine Oxidase Inhibitors are Indicated for use with Barbiturates because they shorten the length of action, decreasing side effects.

Selecione uma das opções:

  • VERDADEIRO
  • FALSO

Explicação

Questão 14 de 15

1

What statement below is accurate regarding the changes the amounts of BDNF in the brain of depressed patients?

Selecione uma das seguintes:

  • There is an INCREASE in the amount of BDNF in the Hippocampus and a DECREASE in the amount of BDNF in the Nucleus Accumbens

  • There is an INCREASE in the amount of BDNF in BOTH the Hippocampus and the Nucleus Accumbens.

  • There is a DECREASE in the amount of BDNF in BOTH the Hippocampus and the Nucleus Accumbens.

  • There is a DECREASE in the amount of BDNF in the Hippocampus and an INCREASE in the amount of BDNF in the Nucleus Accumbens.

Explicação

Questão 15 de 15

1

Which class of anti-depressants cause the "Cheese Effect"

Selecione uma das seguintes:

  • MAOIs

  • SSRIs

  • NMDA Blockers

  • SNRIs

Explicação