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Medicine related kidney questions

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Kidney 2

Questão 1 de 19

1

Sodium enters passively down the membrane down its concentration gradient. It is actively extruded across the basolateral membrane by the Na/K/ATPase pump. Na+ reabsorption is in the PCT, followed by the LOH, DCT and CD.
In the PCT- exchanger at the apical membrane, at the basolateral membrane NA/K/ATPase and Na/HCO3 transporter.
In the thick limb of the LOH - cotransporter (NKCC2)...which can be inhibited by , leading to increased sodium in the DCT and therefore less water loss.
Na transport in the DCT is via transcellular reabsorption (Na/Cl transporter NCC)--thiazide diuretics can inhibit this.
In the cortical collecting duct, Na transport is mediated primarily by the principle cells. It crosses through ENAC's and can be inhibited by amiloride. reabsorption in the proximal tubule is linked to Na+ reabsorption.

Arraste e solte para completar o texto.

    apical
    largest
    least
    Na/H
    Na/Cl-
    Na/K
    Na/K/Cl
    Na/HCO3
    Na/Glucose
    frusemide
    thiazide
    aldosterone
    Water
    chloride
    glucose

Explicação

Questão 2 de 19

1

Selecione das listas do Menu para completar o texto.

( Angiotensin 2, Angiontensin 1 ) binds to AT1 receptors of the proximal tubule. They also stimulate Na-H exchange in the TAL and ENAC's in the initial collecting tubules. All promote ( sodium, calcium, potassium ) reabsorption.
Aldosterone stimulates sodium reabsorption by the initial tubule and CCT. It upregulates apical ENAC's and therefore Na+ permeability.
ADH- overall effect is to produce urine which a ( high, low ) osmolality. In the TAL, ADH stimulates NKCC2 receptors and K+ channels. In the principle cells of the initial collecting tubule and CCT, ADH stimulates Na+ transport by increasing the number of open Na+ channels.

Explicação

Questão 3 de 19

1

Preencha os espaços em branco para completar o texto.

Most of the K is absorbed in the as well. The cell is the Major Regulator of Potassium with % of potassium being managed here.
The Epithelial Na Channels gets us to dump all the potassium by an gradient
The sodium delivered the more potassium dumped. In the proximal tubule K+ reabsorption occurs passively and is via solvent drag. In the TAL K+ is reabsorbed paracellularly and through the - contransporter. In the cortical collecting duct- K+ reabsorption by intercalated discs occurs through the apical K+ uptake mediated by the Pump, followed by passively efflux across the basolateral membrane. In the cortical collecting ducts (principle cells), the K+ occurs by active uptake across basolateral membrane, followed by passive diffusion through apical K+ channels.

Explicação

Questão 4 de 19

1

Stimulators of K+ excretion include?

Selecione uma ou mais das seguintes:

  • Increased K+ intake

  • Increased pH

  • Aldosterone

  • ADH

  • Increased sodium delivery

  • Ameloride

  • Thiazides

Explicação

Questão 5 de 19

1

Chloride is reabsorbed via the pathway early in the PCT via solvent drag,
Later in the PCT at the apical memrane via Cl-base exchanger (Cl- out of lumen, Base in), following + out of lumen. At the basolateral membrane via Cl- channels and K/Cl- cotransporter.
In the thick ascending limb via - cotransporter.
In the ducts via paracellular reabsorption, apically via Cl-HCO3- exchanger and Cl- channels basolateral membrane.

Arraste e solte para completar o texto.

    paracellular
    transcellular
    Na
    Ca
    K
    Na/K/2Cl
    Cl/HCO3-
    collecting
    distal

Explicação

Questão 6 de 19

1

What are the two most important regulators of calcium?

Selecione uma das seguintes:

  • Na and PTH

  • PTH and Vitamin D

  • TSH and Vitamin D

  • PTH and K

Explicação

Questão 7 de 19

1

Most (80%) of the phosphate is reabsorbed at the PCT.
Which factors increase phosphate reabsorption?

Selecione uma ou mais das seguintes:

  • high plasma calcium

  • PTH

  • low plasma calcium

  • ADH

Explicação

Questão 8 de 19

1

The pre-renal causes of AKI include?

Selecione uma ou mais das seguintes:

  • Volume expansion

  • Volume depletion

  • GI losses

  • Glomerulonephritis

  • NSAID's

  • Cutaneous losses

  • Bladder Disease

Explicação

Questão 9 de 19

1

Renal causes of AKI include?

Selecione uma ou mais das seguintes:

  • Inflammatory glomerulonephritis

  • Acute tubular necrosis

  • Rhabdomyolysis

  • Extra-tubular obstruction

  • Acute Interstitial Nephritis

  • Nephrotoxicity

Explicação

Questão 10 de 19

1

A serum creatinine level of 2-3 x the normal amount would place the person in which stage of kidney disease?

Selecione uma das seguintes:

  • 1

  • 2

  • 3

Explicação

Questão 11 de 19

1

Which of these is not a novel biomarker for acute kidney injury?

Selecione uma das seguintes:

  • Urinary Neutrophil Gelatinase- Associated Lipocalin

  • Urinary IL-22

  • Urinary IL-18

  • Urinary Kidney-Injury molecule 1

  • Cystatin C

Explicação

Questão 12 de 19

1

Selecione das listas do Menu para completar o texto.

In the RIFLE classification of AKI. Describe the following components.
R- (Risk) = 1.5 x increase in serum creatinine, GFR less 25% or urine output <( 0.5mL, 1mL )/kg per hour for 6 hours
I- (( Injury, Ischaemia )) = 2 x serum creatinine, GFR 50%, or urine output <0.5mL/kg for 12 hours
F- (Failure) = 3 x SC, GFR 75% drop, urine output <0.5mL/kg 24 hours or ( anuria, proteinuria ) 12 hours
L- (Loss) = complete loss of kidney function > ( 4 weeks, 8 weeks, 12 weeks )
E- (ESRD) = > 3 months

Explicação

Questão 13 de 19

1

Acute Tubular Necrosis is due to tubular injury and prolonged disturbances in blood flow. Which of these is not a common histological feature?

Selecione uma das seguintes:

  • Loss of brush border

  • Cell detachment

  • Distal tubule casts

  • Areas of cellular regeneration

  • Low tubule calcium

Explicação

Questão 14 de 19

1

Preencha os espaços em branco para completar o texto.

The classic triad of Acute Interstitial Nephritis is: , Eosinophilia and .
It is most commonly caused by drugs such as , and NSAID's.
It often after halting these.

Explicação

Questão 15 de 19

1

Hyperkalemia is a common problem of AKI. The mainstay of treatments are
- to drive K+ intracellularly
-Resonium which exchanges K+ and Na+ in the large intestine reducing intake
-Insulin and Glucose which drives K+ intracellularly
- to correct myocardium potential

Arraste e solte para completar o texto.

    B2 agonist
    Isotonic Saline
    Digoxin
    Lasix
    Calcium gluconate
    Sodium Hydrate
    Calcium Phosphate

Explicação

Questão 16 de 19

1

Which of these is not a role of the mesangium (the space between the capillaries of glomerulus)?

Selecione uma das seguintes:

  • Provide structural support to glomerulus

  • Contractile components

  • Phagocytic function

  • Sequester iron

  • Proliferation and laying down of collagen

Explicação

Questão 17 de 19

1

Preencha o espaço em branco para completar o texto.

A thin layer of endothelial cells with tight junctions surround the capillary lumen

Explicação

Questão 18 de 19

1

Nephrotic Syndrome is characterised by:

Selecione uma ou mais das seguintes:

  • Large amount of Red Blood Cells

  • Heavy protein > 3.5g/ day

  • Oedema

  • Hyperalbuminaemia

  • Hypoalbuminaemia

  • Lipids

Explicação

Questão 19 de 19

1

NSAID's, ACE-Inhibitors and Diuretics can impair kidney function by?

Selecione uma ou mais das seguintes:

  • Dilation of afferent arteriole

  • Constriction of afferent arteriole

  • Dilation of efferent arteriole

  • Constriction of efferent arteriole

  • Promoting increased perfusion via volume expansion

  • Promoting decreased perfusion via volume contraction

Explicação

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