Effects of Single Base Changes

GAG --> GUG in Sickle Cell Anemia

Mutation in S.C.A

Promotion of non-covalent polymerisation in S.C.A

S.I of Whale & Human Hb

Gene loss in bacteria

Gene inactivation

Small Insertions/Deletion

Whole domains can be inserted as long as...

Cause of Paralogues

Limit of replication

Movement of replicated genes

Gene Rearrangement

% of domain pairs in the same order