Gene silencing

advantages of triple helix....but

why don't triplexes work well?

why is triplex better than anti sense?

sequence selective recognition and cleavage of double stranded DNA

ribozymes

take home message on anti sense and other silencing techniques

RNA interference

siRNA (snall interfering RNA)

the ideal oligonucleotide

Ways to deliver antisense molecules

Uses of anti sense molecules

triple helix technology= triplex

anti sense molecules

modifications to make an anti sense molecule