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Criado por Madeline Luedke
quase 8 anos atrás
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Pharmacology
Neuropharmacology
Psychopharmacology
Neuropsychopharmacology
Drug Actions
Drug Effects
Specific Drug Effects
Non-specific drug effects
Bioavailability
Pharmacokinetics
Absorption
Drug Map
Different routes of administration
Oral (PO)
First-pass metabolism (first-pass effect)
Intravenous (IV)
Intramuscular (IM)
Intraperitoneal (IP)
Subcutaneous (SC)
Inhalation
T
Transdermal
phospholipids
hydrophollic
hydrophobic
Lipid-soluble drugs
passive diffusion
concentration gradient
Ionization
pH scale and ionization
Weak
Environmental factors and Ionization
Ion trapping
Absorption Factors
Blood Brain Barrier
Blood flow and concentration
Cerebral Spinal Fluid (CSF)
Typical Capillaries
Intercellular Clefts
Fenestrations
Pinocytotic Vesicles
Brain Capillaries
Area Postrema | Chemical Trigger Zone (CTZ)
Median Eminence
Placental Barrier
Drug Depots
Depot Binding
Biotransformation
First-Order Kinetics
Half-life
Zero-Order Kinetics
Microsomal Enzymes
Two kinds of biotransformation
Phase 1, Nonsynthetic
Phase 2, Synthetic
Cytochrome P450
Notes on biotransformation
Factors Influencing Drug Metabolism
Enzyme Induction
Enzyme Inhibition
Drug Competition
Genetic Polymorphisms
Acetaldehyde