. L.L. is a 42-year-old woman who underwent an allogeneic stem cell transplant for acute leukemia. Her
initial posttransplant course was uncomplicated;however, 1 month after engraftment (7 weeks posttransplant), the patient developed a fever and rash.A skin biopsy revealed graft-vs.-host disease, forwhich the patient’s tacrolimus dose was increased.L.L. also received high-dose steroids, which caused her fever to resolve and rash to improve. She was maintained on prednisone 30 mg orally once daily.One month later, L.L. presents to the hematology clinic with a worsening dry cough, shortness of breath, fever, and one episode of hemoptysis. Chest CT reveals a left-sided cavitary lesion. The hematologist would like to initiate antiAspergillus
therapy.
Which agent would be best to recommend?
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