Volume of
Distribution
Vd

Vd
Lipo/hydro
PHILIC

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Clearance:
Directly vs
Inversely

Elimination
Half-Life

Half life
vs
Half time

Like
Dissolves
Like

Ion Trapping

Plasma Protein
Binding

Plasma Concen:
Albumin
& Alpha-1 acid
glycoprotein

Plasma Protein
Binding & Vd

Metabolism
Phases
(3)

Perfusion dependent
vs
Capacity dependent

Extraction Ratio
formula

ER > 0.7
ER < 0.3

LOW ER
Drugs

P450 Enzymes:
Inducers vs
Inhibitors

Other enzymes

Polarity &
Elimination

Transport drugs
to urine:

Urine pH
Reabsorption &
Excretion

Metabolism in the
Plasma

Difference between:
Kinetics
Biophasics
Dynamics

Dose Response
Curve:
Efficacy & Potency

Dose Response
Curve:
Affinity for receptor

Agonists
Partial Agonists
Antagonists
Inverse Agonists
(graph)

Drugs administered
together

Therapeutic Index

ED 50

LD 50

Chirality

Enantiomerism

Enantiomerism
in Anesthesia