valecha et al., 2010, vennerstrom et al., 2004
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Criado por Jumai Abioye
aproximadamente 10 anos atrás
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Fechar
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Criado por Jumai Abioye
aproximadamente 10 anos atrás
|
|
Malaria
Life cycle
treatment
What has been driving malaria drug discover
Artemisinin
Mode of Action
Anticancer therapy
No longer used as a drug?
Pharmacology
Issues
Why
Ways?
Natural: Artemisia annua
Chemical: artemisin
Chemical; alternatives- synthetic peroxides
Trioxolane
Trioxolane: Arterolane maleate with piperaquine
Avoiding resistance
vote for arterolane and other drugs
Key features included low product costs
requiring a straightforward synthesis and simple formulation
approaches, a maximum 3-day treatment regimen with once-daily
administration necessitating good potency and pharmacokinetic properties, low potential for toxicity and no evidence for resistance development... Vennerstrom et al., 2004
SynriamTM
Artemisinin Resistance
Synthetic
