1. Which of these drugs is used to treat an ADR?
a. Aspirin
b. Paracetamol
c. N-acetylcysteine
d. Chloramphenicol

2. What is the definition of “off-target” ADRs?
a. ADR targeting unknown receptors
b. ADRs linked with receptor targets outside BBB
c. ADRs occurring at unintended targets
d. ADR linked with intended receptor target

3. Aspirin given for preventing blood clots causing GIT bleeding would represent:
a. “On-target” ADR
b. “Off-target” ADR
c. Idiosyncratic ADR
d. Exaggerated ADR

4. What is the definition of Type F ADR according to Australian classification scheme for ADRs?
a. Expected failure of therapy
b. Unexpected failure of therapy
c. Dose-related failure of therapy
d. Delayed failure of therapy

5. Type F ADRs are often caused by:
a. Abrupt drug treatment discontinuation
b. Delayed and not dose related effects
c. Drug interactions
d. Long-term and high dose drug use

6. Paracetamol toxicity was normally prevented by liver synthesis of:
a. Acetaminophen
b. Glucuronyl transferase
c. N-acetyl cysteine
d. Glutathione

7. Liver Phase II reactions are fully developed after:
a. 1 month of life
b. 2 months of life
c. 3 months of life
d. 4 months of life

8. Gray Baby Syndrome develops because of:
a. Circulatory collapse
b. Excessive diarrhoea
c. Impaired liver glucoronisation reaction
d. Impaired liver acetylation reaction

9. Gasping baby syndrome is caused by increased levels of:
a. Benzyl alcohol
b. Benzoic acid
c. Hippuric Acid
d. Benzaldehyde

10. Teratogens are substances that cause:
a. Defects in mother’s placenta
b. Birth defects in foetus
c. Vomiting in pregnant women
d. Bleeding in pregnant women

11. Food and herbal supplements should be investigated carefully in people treated with drugs because:
they could induce drug metabolism
They could inhibit drug metabolism
They may compete with drugs for ADME
All of the above

Why is important to immediately report any unexpected ADRs observed in practice? A. Because ADRs could only occur in patients who are taking drugs at home
B. Because clinical studies cannot identify ADRs
C. Because it is a job of health care provider to report all ADRs
D. Because rare ADRs could only be observed in large patient population

13. Clinical study Phase 3 typical design includes:
a. Healthy volunteers
b. Initial screen for therapeutic activity
c. Experimental group vs. control group
d. Post-marketing drug evaluation

14. “Reptilian”, primitive or instinctive brain function is to:
a. Allow us to find the best solution in complex situations
b. Suppress our aggression
c. Control our tribal and territorial behaviour
d. Support our instinctive survival

15. Autonomic nervous system is a part of:
a. Sympathetic nervous system
b. Parasympathetic nervous system
c. Sensory nervous system
d. Motor nervous system

16. Which muscle type is NOT an effector of ANS?
a. Skeletal muscle
b. Cardiac muscle
c. Smooth muscle
d. Gland muscle

Autonomic nervous system conduction is slower because of:

acetylcholine can be inhibitory or excitatory

the affect of ACh could either be inhibitory or excitatory because: