DNA

What is the axial rise of DNA?

What form is the guanine base in B-DNA?

What form does the sugar adopt in B-DNA?

What form does the sugar adopt in B-DNA?

What makes the major and minor grooves equal depth?

What form does the glycosidic bond adopt in B-DNA?

Describe the major and minor grooves in A-DNA?

Describe Z-DNA?

What is a hairpin?

What is thermal melting?

What is hypochromicity and what does it result from??

What happens to UV absorbance after denaturing?

What is the melting temperature of DNA, how is this obtained?

What does the melting temperature of a duplex depend on?

Why does Tm increase with increasing salt concentration?

Why is the Tm of a hairpin independent of duplex conc?

What small molecules interact with DNA at the minor and major grooves?

What does intercalation of base pairs occur with?

What is the different between (-) and (+) strands in viruses?

How is acyclovir converted from a prodrug into its active form?

How does acyclovir triphosphate terminate DNA synthesis?

Why cant acyclovir triphosphate be used as the drug?

Why is AZT toxic?

How does AZT inhibit DNA synthesis?

Describe the 5 steps in the mechaism of AZT

What is a nucleoside?

What is the difference between the OH groups in RNA and DNA? Why?

What are the purines and what are the pyrimidines?

What replaces uracil in RNA?

How is a nucleotide formed from a nucleoside?

At what position does the phosphate bridge in DNA and RNA?

What is the association of 2 individual strands of DNA stabilised by?

What is the helical turn of DNA?