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may be due to decreased blood pH, increased carbon dioxide (PaCO2), elevated temperature, and/or increased 2,3 DPG. When shifted right, oxygen is more easily detached from hemoglobin, enhancing delivery to tissues, even at lower oxygen saturation levels.
may be due to increased blood pH, decreased carbon dioxide, decreased temperature, and/or decreased 2,3 DPG. When the curve is shifted left, the bond between oxygen and hemoglobin is stronger and it is more difficult for hemoglobin to release oxygen to the tissue. Even if oxygen saturation is higher, tissue hypoxia may result.