1308146
Descrição
Quiz por Peter Seymour, atualizado more than 1 year ago
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Criado por Peter Seymour
aproximadamente 10 anos atrás
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Questão 1
Questão
A rapidly dividing cell will have a greater abundance of which nucleotide?
Responda
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Guanine and Adenine because purine synthesis is more important for a developing cell
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Cytosine and Thiamine because pyrimidine synthesis is less taxing and therefore proceed more quickly
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The concentration of pyrimidines and purines will be equal regardless of the conditions
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Purines are critical for DNA replication, so purine concentration will be higher
Questão 2
Questão
Which of the following is a nucleotide?
Responda
-
Image:138px-Adenin.svg (image/png)
Questão 3
Questão
For the previous question why was the correct answer the only nucleotide?
Responda
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It was the only answer that consisted of a nucleoside bound to a phosphate group
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All of the other answers were sugars
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All of the other answers were bases
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None of the other answers were biologically important molecules
Questão 4
Questão
Which of the following is not a biological function of Nucleotides?
Responda
-
They are precursors to glycogen and other phosphoglycerides
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Nucleotides exclusively compromise the universal energy currency
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They serve as metabolic regulators and mediate the action of many hormones
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Nucleotides entirely make up three major co-enzymes: NADH, FAD, and CoA
Questão 5
Questão
cAMP is a nucleotide that mediates hormones
Responda
- True
- False
Questão 6
Questão
Purine biosynthesis involves which of the following precursors?
Responda
-
Glycine
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Glutamine
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Aspartate
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carbon dioxide
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Formyltetrahydrofolate
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All of the above are required atom contributors
Questão 7
Questão
PRPP (Phosphoribosylpyrophosphate) is the source of the ribose sugar in...
Responda
-
purine de novo synthesis and purine salvage pathways
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purine de novo synthesis
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purine salvage
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purine and pyrimidine de novo synthesis
Questão 8
Questão
Which describes the committed step for purine de novo synthesis?
Responda
-
Glutamine-PRPP amido-transferase is the active enzyme
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PRPP feeds into the committed step
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Glutamine feeds into the step and becomes glutamate
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All of the above
Questão 9
Questão
THF is an enzyme that performs which of the following actions?
Responda
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Eliminates an amide group
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Transfers one carbon from N10-Formyl THF to the growing purine precursor
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Allosterically activates HGRPT
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Facilitates a Glutamine dependent nitrogen tranfer
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Facilitates ring closure of the growing purine
Questão 10
Questão
The base hypoxanthine is described by which of the following statements?
Responda
-
Inosinic Acid (IMP) is the nucleoside form of hypoxanthine
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Hypoxanthine is critical only to the conversion of IMP to GMP not IMP to AMP
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Hypoxanthine is reduced to xanthine during the purine synthesis pathway
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The oxidation of hypoxanthine to xanthine is blocked by allpurinol
Questão 11
Questão
PRPP impacts which of the following?
Responda
-
De novo synthesis of purines
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Direct production of IMP through PRPP's reaction with Hypoxanthine
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Direct production of GMP through PRPP's reaction with Guanine
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All of the above are catalyzed by HGPRT and all are true in healthy cells
Questão 12
Questão
Which of the following is deficient in Gout?
Responda
-
HGPRT
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ADA (adenosine deaminase)
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PNP (purine nucleoside phosphorylase)
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You have to be more specific, gout could be the result of numerous enzyme deficiencies
-
XO (xanthine oxidase)
Questão 13
Questão
Lesch Nyhan Syndrome is caused by a deficiency in which of the following?
Responda
-
PRPP
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XO (xanthine oxidase)
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ADA (adenosine deaminase)
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HGPRT
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You have to provide more information, Lesch Nyhan Syndrome could be caused by the deficiency of a number of different enzymes
Questão 14
Questão
Which is the committed step of Pyrimidine synthesis?
Responda
-
Aspartate Transcarbamoylase ATCase
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Dihydroorotase
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OPRT
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CTP synthetase
Questão 15
Questão
Familial Orotic Aciduria can be treated using which of the following methods?
Responda
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There is no curative treatment, simply a management of symptoms
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Delivery of large doses of orally administered uridine to simply bypass the early steps of pyrimidine synthesis
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Delivery of large doses of the missing/deficient orotate phosphoribosyltransferase (OPRT)
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Delivery of fully synthesized pyrimidines for uptake into the cell
Questão 16
Questão
Which of the following are made by a two enzyme complex (Thymidylate Synthetase and Dihydrofolate reductase) after ribonucleotide reductase acts on freshly minted purines and pyrimidines?
Responda
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dADP
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dGDP
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dCDP
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dUDP
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dTTP
Questão 17
Questão
dATP is the master negative regulator of Ribonucleotide Reductase.
Responda
- True
- False
Questão 18
Questão
Which of the following enzymes should I know really well?
Responda
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Ribosomyl Reductase
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PRPP Synthetase
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Xanthine Oxidase
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Dihydrofolate Reductase
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HGPRT
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Amidophosphoryl Transferase ATase = glutamine PRPP amidotransferase
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I should probably know all of these
Questão 19
Questão
Why do we use "De Novo" instead of saying from scratch?
Responda
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Because Carl Sagan's famous Apple Pie from scratch comment makes it too awesome to use in any setting other than musing about the universe
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Because De Novo is more descriptive
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To confuse those who are sadly lacking in medical jargon
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Because fancy language is awesome
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