2812487
Descrição
Quiz por Alexandra McCabe, atualizado more than 1 year ago
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Criado por Alexandra McCabe
aproximadamente 9 anos atrás
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Questão 1
Questão
What is the best way to assemble a genome?
Responda
-
Have a reference gene to different species
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Have a reference gene to same species
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Have a reference genome to same species
-
Have a reference genome to different species
Questão 2
Questão
Which is better DNA plat forms?
Responda
-
Shorter reads cause of lower accurancy
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Longer reads easier to assemble
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Shorter reads cause of higher accurancy
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Longer reads harded to assemble
Questão 3
Questão
What happens next after you have fragments?
Responda
-
Place contigs together to see where they fit on the reference genome
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Place contigs together next to eachother
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Analyse each contig
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Place contigs far apart
Questão 4
Questão
How do you increase the coverage for genome sequencing?
Responda
-
Decrease the number of sequencing
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Increase the number of sequencing
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Use more DNA
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Use reference DNA
Questão 5
Questão
Sequence gap:
Responda
-
Don't have enough sequence but know the order and orientation of the contigs
-
No information about the adjacent gap or spanning gap
Questão 6
Questão
Physical Gaps:
Responda
-
No information about the adjacent gap or spanning gap
-
Know the order and orientation of the contigs but dont have enough sequence
Questão 7
Questão
What is the function of genome scaffolds?
Responda
-
Rearrange the genome
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Rearrange gene
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Construct and arrange contigs in relation to one another
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Place contigs on a stiff sufface
Questão 8
Questão
What step is after contig production when you are trying to build a gemone?
Responda
-
Genome scaffolds with gaps in between contigs
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Join contigs using evidence from pair end data
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Place the contigs right next to eachother with no gaps
Questão 9
Questão
Why would you no fill the gap that is found between contigs on the genome scaffold?
Responda
-
A customer might only want a scaffold of the genome
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Gaps can be over looked
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Customer might want to fill it in himself
Questão 10
Questão
What does N50 mean?
Responda
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The value of which 50% of nucleotides sequences are represented
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The percentage of gaps in the scaffold
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The number of genes produced
Questão 11
Questão
A k-mer are nucleotides that have been cut down to a certain size
Responda
- True
- False
Questão 12
Questão
What is the function of a contig?
Responda
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Represent a consensus region of DNA
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Represent the genome
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Represent the gene
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Represent a consensus region of RNA
Questão 13
Questão
How can you guess gap sizes on scaffold?
Responda
-
Incorporating info from pair ends of the contigs
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Randomly guess
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Place all the contigs beneath each other
Questão 14
Questão
Long insert library
Responda
-
4-40 kb library that has 100 bp on each end
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4-8 kb library that has 100 bp on each end
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4-40 kb library that has 10 bp on each end
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4-8 kb library that has 10 bp on each end
Questão 15
Questão
Why is De Novo genome assembly useful?
Responda
-
Suitable for short coverage and long reads
-
Suitable for long coverage and long reads
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Suitable for long coverage and short reads
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Suitable for short coverage and short reads
Questão 16
Questão
Why is the De Bruijn Graph useful?
Responda
-
Suitable for high coverage and long reads
-
Suitable for high coverage and short reads
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Suitable for short coverage and long reads
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Suitable for short coverage and short reads
Questão 17
Questão
How long do the k-mers need to be in overlap-layout-consensus?
Responda
-
approx 24
-
approx 2
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approx 240
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approx 2400
Questão 18
Questão
Why do the k mers in the De Bruijn model need to be similar sizes?
Responda
-
If they are too small, it won't show overlaps
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If they are too long, it won't show overlaps
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If they are too small is easier to sequence
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If they are too long is easier to sequence
Questão 19
Questão
What is problem that arises when assembling fragments?
Responda
-
Repeats
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mRNA
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cDNA
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gDNA
Questão 20
Questão
How do you solve the problem of repeats in genome assembly?
Responda
-
Increase reading length which decreases sequence error rate
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Increase reading length which increases sequence error rate
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Decrease reading length which decreases sequence error rate
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Decrease reading length which increases sequence error rate
Questão 21
Questão
What takes up 45% of the genome?
Responda
-
Large duplications
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Simple repeats
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Introns and Exons
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Transposons
Questão 22
Questão
Intergenic DNA have parasitic DNA that often fail to replicate properly
Responda
- True
- False
Questão 23
Questão
What is the name of the process whereby an exon from Gene A is placed in Gene B?
Responda
-
Exon duplication
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Exon Shuffling
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Intron Duplication
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Intron Shuffling
Questão 24
Questão
What is the process whereby an exon is repeated and forms a new gene variant?
Responda
-
Exon Duplication
-
Exon Shuffling
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Intron Duplication
-
Intron Shuffling
Questão 25
Questão
Entire gene families can be duplicated
Responda
- True
- False
Questão 26
Questão
What happens when entire gene super families get duplicated?
Responda
-
Can double the number of copies of every gene and gene family
-
Can half the number of copies of every gene and gene family
Questão 27
Questão
What happens when misaligned chromatids
Responda
-
Repeats
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Transposons
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Exons
-
Introns
Questão 28
Questão
Homologous genes in different organisms that encode proteins with the same function and have evolved by direct vertical descent
Responda
-
Orthologous Genes
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Paralogous Genes
Questão 29
Questão
Homologous genes within an organism encoding proteins with related functions and often arise due to gene duplication
Responda
-
Orthologous genes
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Paralogous genes
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